• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2013 Fiscal Year Final Research Report

Development of New Biological Therapy for Regeneration of Degenerated Interbvertebral Discs

Research Project

  • PDF
Project/Area Number 23592162
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Orthopaedic surgery
Research InstitutionGifu University

Principal Investigator

MIYAMOTO Kei  岐阜大学, 医学(系)研究科(研究院), 准教授 (20313885)

Co-Investigator(Kenkyū-buntansha) SHIMIZU Katsuji  岐阜大学, 大学院医学研究科, 教授 (90170969)
Project Period (FY) 2011 – 2013
Keywordscalpain / intervertebral disc / degeneration / anti aging / spine / yelolow ligament
Research Abstract

Influences of anti-inflammatory drugs and calpain on dintervertebral disc (IVD) degeneration were investigated in order to develop new biological treatment for degenerated IVD. Additionally, expression of calpain was examined in ossificication of yellow ligament (OYL) at thoracolumbar region associated with IVD degeneration. While Celecoxib and Indomethacin decreased production of inflammatory products in cultured bovine IVD cells with addition of interleukin-1, Celecoxib decreased expression of calpain in cultured medium. This suggested that use of calpain has some role in the anti-inflammatory function of Celecoxib for degenerated IVD. Expression of calpain in OYL was shown, suggesting that regulation of calpain can have a role in inhibition of development in OYL.

  • Research Products

    (4 results)

All 2014 2012 Other

All Journal Article (1 results) Presentation (2 results) Remarks (1 results)

  • [Journal Article] ヒト椎間板変性におけるカルパインの影響2012

    • Author(s)
      福田章二,宮本敬,鈴木毅一,井上俊之,喜久生健太,清水克時
    • Journal Title

      中部日本整形外科・災害外科学会雑誌

      Volume: Vol.55No.5 Pages: 94

  • [Presentation] 高齢者における腰痛下肢痛の診断・説明・治療2014

    • Author(s)
      宮本敬
    • Organizer
      第9回老化と生活習慣病を考える会
    • Place of Presentation
      岐阜市
    • Year and Date
      2014-05-29
  • [Presentation] Surgical treatment for infected spine using spinal instrumentation2014

    • Author(s)
      Kei Miyamoto
    • Organizer
      23rd Myanmar Orthopaedic Society Biennial Conference
    • Place of Presentation
      Myanmar
    • Year and Date
      2014-02-08
  • [Remarks] 岐阜大学整形外科 基礎研究 脊椎脊髄研 究 ホームページ

    • URL

      http://hosp.gifu-u.ac.jp/seikei/

URL: 

Published: 2015-07-16  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi