2013 Fiscal Year Final Research Report

Development of New Biological Therapy for Regeneration of Degenerated Interbvertebral Discs

Research Project

Project/Area Number	23592162
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Orthopaedic surgery
Research Institution	Gifu University
Principal Investigator	MIYAMOTO Kei 岐阜大学, 医学(系)研究科(研究院), 准教授 (20313885)
Co-Investigator(Kenkyū-buntansha)	SHIMIZU Katsuji 岐阜大学, 大学院医学研究科, 教授 (90170969)
Project Period (FY)	2011 – 2013
Keywords	calpain / intervertebral disc / degeneration / anti aging / spine / yelolow ligament
Research Abstract	Influences of anti-inflammatory drugs and calpain on dintervertebral disc (IVD) degeneration were investigated in order to develop new biological treatment for degenerated IVD. Additionally, expression of calpain was examined in ossificication of yellow ligament (OYL) at thoracolumbar region associated with IVD degeneration. While Celecoxib and Indomethacin decreased production of inflammatory products in cultured bovine IVD cells with addition of interleukin-1, Celecoxib decreased expression of calpain in cultured medium. This suggested that use of calpain has some role in the anti-inflammatory function of Celecoxib for degenerated IVD. Expression of calpain in OYL was shown, suggesting that regulation of calpain can have a role in inhibition of development in OYL.