2013 Fiscal Year Final Research Report
Development and evaluation of an injectable bone substitute with bioresorbability
| Project/Area Number |
23592179
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
AE Keisuke 東京医科歯科大学, 医学部, 非常勤講師 (20376726)
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| Co-Investigator(Kenkyū-buntansha) |
SOTOME Shinichi 東京医科歯科大学, 大学院医歯学総合研究科, 寄附講座准教授 (20401391)
OKAWA Atsushi 東京医科歯科大学, 大学院医歯学総合研究科, 教授 (30251507)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 注入硬化型骨補填材 / ハイドロキシアパタイト・コラーゲン複合体 / リン酸カルシウムセメント |
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| Research Abstract |
The use of artificial bone grafts have increased because of its development. In general, bone graft surgery is relatively invasive. To realize less invasive implantation, some injectable artificial bone substitutes were developed. However their resorbabilities were very low and the implants were scarcely resorbed. The aim of this study was to develop and evaluate an injectable artificial bone substitute with bioresorbability and mehcanical strenght comparable to that of cancellous bone. The developed injectable bone substitute was consist of dense granule of hydroxyapatite/collagen composite (HAp/Col) and calcium phosphate cement. Compression test revealed taht the compression strength of the consolidated bone substitute was comparable to that of cancellous bone. Implantation experiment showed that resorption of the implant started mainly from the HAp/Col granules and the bone formation was occured at the resorption sites.
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Research Products
(12 results)
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[Journal Article] After repeated division, bone marrow stromal cells express inhibitory factors with osteogenic capabilities, and EphA5 is a primary candidate2013
Author(s)
Yamada T, Yuasa M, Masaoka T, Taniyama T, Maehara H, Torigoe I, Yoshii T, Shinomiya K, Okawa A, Sotome S
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Journal Title
Bone
Volume: 57(2)
Pages: 343-54
DOI
Peer Reviewed
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[Journal Article] Massive bone reconstruction with heat-treated bone graft loaded autologous bone marrow-derived strom al cells andβ-tricalcium phosphate composites in canine models2013
Author(s)
Koyanagi H, Ae K, Maehara H, Yuasa M, Masaoka T, Yamada T, Taniyama T, Saito M, Funauchi Y, Yoshii T, Okawa A, Sotome S
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Journal Title
J Orthop Res
Volume: 31(8)
Pages: 1308-16
DOI
Peer Reviewed
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[Journal Article] Porous/dense composite hydroxyapatite for anterior cervical discectomy and fusion2013
Author(s)
Yoshii T, Yuasa M, Sotome S, Yamada T, Sakaki K, Hirai T, Taniyama T, Inose H, Kato T, Arai Y, Kawabata S, Tomizawa S, Enomoto M, Shinomiya K, Okawa A
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Journal Title
Spine (Phila Pa 1976)
Volume: 38(10)
Pages: 833-40
DOI
Peer Reviewed
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[Journal Article] Hybrid grafting using bone marrow aspirate combined with porousβ-tricalcium phosphate and trephine bone for lumbar posterolateral spinal fusion : a prospective, comparative study versus local bone grafting2012
Author(s)
Yamada T, Yoshii T, Sotome S, Yuasa M, Kato T, Arai Y, Kawabata S, Tomizawa S, Sakaki K, Hirai T, Shinomiya K, Okawa A
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Journal Title
Spine (Phila Pa 1976)
Volume: 37(3)
Pages: E174-9
DOI
Peer Reviewed
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[Presentation] Massive bone reconstruction with heat-treated bone graft loaded autologous bone marrow derived stromal cells and beta-tricalcium phosphate composites in canine models2013
Author(s)
Koyanagi H, Ae K, Yuasa M, Masaoka T, Yamada T, Taniyama T, Yoshii T, Saito M, Okawa A, Sotome S
Organizer
59th Annuial meeting of the orthopaedic research society
Place of Presentation
San Antonio, Texas
Year and Date
20130126-29
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