2014 Fiscal Year Final Research Report
Target therapy for bone and soft tissue sarcoma
| Project/Area Number |
23592189
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Kagawa University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
HORIE Ryouseke 香川大学, 医学部附属病院, 病院助教 (50645827)
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| Project Period (FY) |
2011-04-28 – 2015-03-31
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| Keywords | 骨軟部腫瘍 / オートファジー / アポトーシス / mTOR |
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| Outline of Final Research Achievements |
We examined target therapy of mTOR pathway using human bone and soft tissue sarcoma cell lines (MG63, Nara-H Cell). Our present study suggested that self protective mechanisms involving mTOR inhibitors in sarcoma cells are prevented by the inhibition of autophagy. The combination of an mTOR inhibitor and an autophagy inhibitor may offer effective treatment for sarcoma, as this combination effectively activates apoptotic pathways.
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| Free Research Field |
整形外科
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