2013 Fiscal Year Final Research Report
Elucidation of the mechanism of action of anti-RANKL antibody for treatment of metabolic bone disease.
| Project/Area Number |
23592204
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TANAKA Sakae 東京大学, 医学部附属病院, 教授 (50282661)
MIURA Toshiki 東京大学, 医学部附属病院, その他 (20376479)
KADONO Yuho 東京大学, 医学部附属病院, 講師 (70401065)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 骨・軟骨代謝学 |
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| Research Abstract |
Anti-RANKL antibody is one of the most successful therapeutics for osteoporosis. The aim of this study was to elucidate the effect of the individual and combined effects of PTH and anti-RANKL monoclonal antibody in ovariectomized mice. This study suggest that co-treatment PTH with anti-RANKL antibody may make additive effect in BMD and the possibility of difference in optimal duration and effective regions.
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