2014 Fiscal Year Final Research Report
The potential usefulness and limitation of urinary CTX-II in estimating X-ray osteoarthritis knee progression : a longitudinal cohort study
| Project/Area Number |
23592207
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Niigata University |
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Principal Investigator |
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| Project Period (FY) |
2011-04-28 – 2015-03-31
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| Keywords | 変形性膝関節症 / バイオマーカー / 尿中CTX-II / 縦断研究 / 住民検診 |
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| Outline of Final Research Achievements |
Biomarkers for knee osteoarthritis are quite important in estimating onset and progression of OA. To investigate the relationship between radiological knee OA changes and values of urinary CTX-II, one of candidate biomarkers of knee OA, in Japanese, we performed longitudinal population-based cohort study for three years. Urinary CTX-II was significantly higher in the OA progression group than that in the OA non-progression group in female. We further performed X-ray evaluation of knee OA at six years and found that uCTX-II values became significantly higher at three years than those at the start point in OA onset group of both gender. In addition, cases with higher values of mean uCTX-II had higher numbers of knee OA progression cases in both gender. These findings suggest that repeated measurements of uCTX-II could estimate the onset and progression of knee OA in Japanese.
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| Free Research Field |
整形外科
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