2013 Fiscal Year Final Research Report
Chewing ameliorates stress-induced osteoporosis in mouse
| Project/Area Number |
23592208
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Gifu University |
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Principal Investigator |
AZUMA Kagaku 岐阜大学, 医学(系)研究科(研究院), 講師 (20273146)
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| Co-Investigator(Kenkyū-buntansha) |
KUBO Kinya 星城大学, 健康支援学研究科, 教授 (00329492)
ONOZUKA Minoru 神奈川歯科大学, 歯学部, 名誉教授 (90084780)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 骨粗鬆症 |
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| Research Abstract |
We examined the effect of chewing on stress-induced bone loss in mice. SAMP8 was randomly divided into control, stress, and chewing groups. Mice in the stress and chewing groups were placed in a ventilated restraint tube for 60 minutes, twice a day for 4 weeks. Mice in the chewing group were allowed to chew a wooden stick during the experimental period. Bone response was evaluated using micro CT and biochemical markers. Exposure of SAMP8 mice to stress resulted in significant increase of the blood corticosterone and noradrenaline levels. The bone resorption was activated and the bone formation was suppressed. Trabecular bone volume was decreased in the stress group. Chewing under chronic stress prevented the increase in the blood corticosterone and noradrenaline levels, attenuated the reduced bone formation and increased bone resorption, improved the trabecular bone loss induced by chronic stress. These findings indicate that chewing can ameliorate stress-induced bone loss in mice.
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[Journal Article] Polyglutamine expansion disturbs the endoplasmic reticulum formation, leading to caspase-7 activation through Bax2014
Author(s)
Ueda M, Li S, Itoh M, Hayakawa-Yano Y, Wang MX, Hayakawa M, Hasebe-Matsubara R, Ohta K, Ohta E, Mizuno A, Matsumoto M, Chen H, Hida Y, Nakagawa T
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Journal Title
Biochem Biophys Res Commun
Volume: 443
Pages: 1232- 8
Peer Reviewed
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[Book] Osteoporosis2012
Author(s)
ChenH, Hayashi T, Zhou X, Fujita H, Onozuka M, Kubo KY
Total Pages
181-194
Publisher
Intech Open Access Publisher
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