2013 Fiscal Year Final Research Report
Non-invasive treatment of rotator cuff tear by using mesenchymal stem cells
| Project/Area Number |
23592210
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Shiga University of Medical Science |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
IMAI Shinji 滋賀医科大学, 医学部, 准教授 (90283556)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 腱板 / 修復 / 骨髄間葉系細胞 / サル |
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| Research Abstract |
Four-mm and 8-mm width defects were created to the shoulder of cynomolgus monkeys to investigate critical size for spontaneous healing. Transosseous passageways were also created in adjacent to the 4-mm and 8-mm defects. Four-mm defects spontaneously healed, whereas the 8-mm defects did not. The present study demonstrated that creation of the transosseous passageway reversed the recurrence of 8-mm defects.
Bone marrow-derived MSCs were isolated. Eight-mm defects were created at the tendon insertion of the rotator cuff and were either left untreated (Null group) or injected with MSC (MSC group). The Null group showed most cartilage-rich reparative tissue covering the defect, owing to formation of excessive tendon extruding though the insufficient subchondral bone. Despite less amount of new reparative tissue produced, the MSC group demonstrated better quality of tendon repair with regular surface and reconstruction of trabecular subchondral bone.
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[Journal Article] Brain-derived neurotrophic factor from bone marrow-derived cells promotes post-injury repair of peripheral nerve2012
Author(s)
Takemura Y, Imai S, Kojima H, Katagi M, Yamakawa I, Kasahara T, Ueba H, Terashima T, Yasuda H, Chan L, Kimura H, Matsusue Y
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Journal Title
PLos One
Volume: 7
Pages: e44592
Peer Reviewed
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