2013 Fiscal Year Final Research Report
Investigation for gene regulating factors in articular cartilage degeneration
| Project/Area Number |
23592218
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Kyushu University |
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Principal Investigator |
OKAZAKI KEN 九州大学, 大学病院, 講師 (10398092)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 関節炎 / 軟骨 / 遺伝子発現 / 転写因子 |
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| Research Abstract |
We found that a transcriptional factor, C/EBP plays crucial roles in gene regulation which affect cartilage degeneration in osteoarthritis or rheumatoid arthritis. C/EBP stimulates gene expressions of MMP1, MMP-3, MMP-13, which denature the cartilage matrix. C/EBP also stimulate RANKL expression to promote osteoclast formation that consequently promote bone destruction in rheumatoid arthritis. Furthermore, C/EBP repress the expression of type II collagen which is a major matrix molecule of cartilage.
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