2013 Fiscal Year Final Research Report
Investigation of gastrectomy-induced bone pathology and treatment: an approach from stomach-liver-bone axis
| Project/Area Number |
23592229
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Wakayama Medical University |
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Principal Investigator |
UEDA Kazuki 和歌山県立医科大学, 医学部, 博士研究員 (50405437)
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| Co-Investigator(Kenkyū-buntansha) |
UEYAMA Takashi 和歌山県立医科大学, 医学部・解剖学第一, 准教授 (50264875)
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| Project Period (FY) |
2011 – 2013
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| Keywords | Bone histomorphometry / parietal cells / stomach / transcriptosome |
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| Research Abstract |
Using a gastrectomy (GX) rat model, we showed that GX induced high turnover of bone with hyperosteoidosis, prominent increase of mineralization and increased mRNA expression of both osteoclast-derived tartrate-resistant acid phosphatase 5b and osteocalcin. The increased 1, 25(OH)2D3 level and unchanged PTH and calcitonin levels suggested that conventional bone and Ca metabolic pathways were not involved or changed in compensation. Thus, GX-induced bone pathology was different from a typical osteomalacia.
Gene expression profiles through microarray analysis and data mining using Ingenuity Pathway Analysis indicated that 612 genes were up-regulated and 1,097 genes were down-regulated in the GX bone. Network analysis indicated 9 genes were hubs connected with tissue development and immunological diseases. These results suggest that chronic systemic inflammation might underlie the GX-induced pathological changes in bone.
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[Journal Article] Nrf2-induceding anti-oxidation stress response in the liver - New beneficial effect of Lansoprazole2014
Author(s)
Yamashita Y, Ueyama T, Nishi T, Yamamoto Y, Kawakoshi A, Sunami S, Iguchi M, Tamai H, Ueda K, Ito T, Tsuruo Y, Ichinose M
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Journal Title
PLoS ONE
Volume: 9(5)
Pages: e97419
DOI
Peer Reviewed
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