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2013 Fiscal Year Final Research Report

Regulation of osteoclastogenesis by transcriptional repressor Blimp1 via epigenetic regulation

Research Project

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Project/Area Number 23592231
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Orthopaedic surgery
Research InstitutionKeio University

Principal Investigator

MIYAUCHI Yoshiteru  慶應義塾大学, 医学部, 共同研究員 (90445411)

Project Period (FY) 2011 – 2013
Keywords破骨細胞
Research Abstract

Osteoclasts are unique bone resorbing cells, and thus are therapeutic targets to treat bone diseases such as osteoporosis. We found that B lymphocyte induced maturation protein 1 (Blimp1), a transcriptional repressor, was required for osteoclastogenesis. Although Blimp1-null mutant mice are embryonic lethal, Blimp1 conditional knockout at an adult stage by a Cre/loxP system did not promote lethal adverse effects in mice, while resulted in significant inhibition of osteoclast formation with increased bone mass. Thus, Blimp1 was considered as a therapeutic target to treat skeletal diseases such as osteoporosis (J Biol Chem 2012).

  • Research Products

    (8 results)

All 2013 2012 2011

All Journal Article (7 results) (of which Peer Reviewed: 7 results) Presentation (1 results)

  • [Journal Article] HIF1αis required for osteoclast activation by estrogen deficiency in postmenopausal osteoporosis2013

    • Author(s)
      Miyauchi Y, Sato Y, Kobayashi T, Yoshida S, Mori T, Kanagawa H, Katsuyama E, Fujie A, Hao W, Miyamoto K, Tando T, Morioka H, Matsumoto M, Chambon P, Johnson RS, Kato S, Toyama Y, Miyamoto T
    • Journal Title

      Proc Natl Acad Sci U S A

      Volume: vol. 110 Pages: 16568-73

    • DOI

      10.1073/pnas.1308755110

    • Peer Reviewed
  • [Journal Article] An essential role for STAT6-STAT1 protein signaling in promoting macrophage cell-cell fusion2012

    • Author(s)
      Miyamoto H, Katsuyama E, Miyauchi Y, Hoshi H, Miyamoto K, Sato Y, Kobayashi T, Iwasaki R, Yoshida S, Mori T, Kanagawa H, Fujie A, Hao W, Morioka H, Matsumoto M, Toyama Y, Miyamoto T
    • Journal Title

      J Biol Chem

      Volume: vol. 287 Pages: 32479-84

    • DOI

      10.1074/jbc.M112.358226

    • Peer Reviewed
  • [Journal Article] Conditional inactivation of Blimp1 in adult mice promotes increased bone mass2012

    • Author(s)
      Miyauchi Y, Miyamoto H, Yoshida S, Mori T, Kanagawa H, Katsuyama E, Fujie A, Hao W, Hoshi H, Miyamoto K, Sato Y, Kobayashi T, Akiyama H, Morioka H, Matsumoto M, Toyama Y, Miyamoto T
    • Journal Title

      J Biol Chem

      Volume: vol. 287 Pages: 28508-17

    • DOI

      10.1074/jbc.M112.356634

    • Peer Reviewed
  • [Journal Article] PDGFBB promotes PDGFRα-positive cell migration into artificial bone in vivo2012

    • Author(s)
      Yoshida S, Iwasaki R, Kawana H, Miyauchi Y, Hoshi H, Miyamoto H, Mori T, Kanagawa H, Katsuyama E, Fujie A, Hao W, Kobayashi T, Sato Y, Miyamoto K, Morioka H, Matsumoto M, Chiba K, Toyama Y, Nakagawa T, Miyamoto T
    • Journal Title

      Biochem Biophys Res Commun

      Volume: vol. 421 Pages: 785-9

    • DOI

      10.1016/j.bbrc.2012.04.084

    • Peer Reviewed
  • [Journal Article] Aldehyde-stress resulting from Aldh2 mutation promotes osteoporosis due to impaired osteoblastogenesis2012

    • Author(s)
      Hoshi H, Hao W, Fujita Y, Funayama A, Miyauchi Y, Hashimoto K, Miyamoto K, Iwasaki R, Sato Y, Kobayashi T, Miyamoto H, Yoshida S, Mori T, Kanagawa H, Katsuyama E, Fujie A, Kitagawa K, Nakayama KI, Kawamoto T, Sano M, Fukuda K, Ohsawa I, Ohta S, Morioka H, Matsumoto M, Chiba K, Toyama Y, Miyamoto T
    • Journal Title

      J Bone Miner Res

      Volume: vol. 27 Pages: 2015-23

    • DOI

      10.1002/jbmr.1634

    • Peer Reviewed
  • [Journal Article] Osteoclast stimulatory transmembrane protein and dendritic cell–specific transmembrane protein cooperatively modulate cell–cell fusion to form osteoclasts and foreign body giant cells2012

    • Author(s)
      Miyamoto H, Suzuki T, Miyauchi Y, Iwasaki R, Kobayashi T, Sato Y, Miyamoto K, Hoshi H, Hashimoto K, Yoshida S, Hao W, Mori T, Kanagawa H, Katsuyama E, Fujie A, Morioka H, Matsumoto M, Chiba K, Takeya M, Toyama Y, Miyamoto T
    • Journal Title

      J Bone Miner Res

      Volume: vol. 27 Pages: 1289-97

    • DOI

      10.1002/jbmr.1575

    • Peer Reviewed
  • [Journal Article] Osteoclasts are dispensable for haematopoietic stem cell maintenance and mobilization2011

    • Author(s)
      Miyamoto K, Yoshida S, Kawasumi M, Hashimoto K, Kimura T, Sato Y, Kobayashi T, Miyauchi Y, Hoshi H, Iwasaki R, Miyamoto H, Hao W, Morioka H, Chiba K, Kobayashi T, Yasuda H, Penninger JM, Toyama Y, Suda T and Miyamoto T
    • Journal Title

      J Exp Med

      Volume: vol. 208 Pages: 2175-81

    • DOI

      10.1084/jem.20101890

    • Peer Reviewed
  • [Presentation] 転写抑制因子Blimp1は骨代謝制御の分子標的である2011

    • Author(s)
      宮内芳輝、戸山芳昭、宮本健史
    • Organizer
      第29回日本骨代謝学会学術集会
    • Place of Presentation
      大阪国際会議場
    • Year and Date
      20110728-30

URL: 

Published: 2015-07-16  

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