2013 Fiscal Year Final Research Report
Role of IL-17 in rheumatoid arthritis and the mechanism of site-specific joint destruction
| Project/Area Number |
23592234
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Toho University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NAKAJIMA Arata 東邦大学, 医学部, 准教授 (60583995)
NAKAGAWA Koichi 東邦大学, 医学部, 教授 (30400823)
AOKI Yasuchika 東邦大学, 医学部, 准教授 (70584001)
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| Project Period (FY) |
2011 – 2013
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| Keywords | リウマチ病学 / 免疫学 |
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| Research Abstract |
To determine the percentage of IL-17-positeive cells and IL-17-expressing cell types in the rheumatoid synovium, immunohistochemical staining for IL-17 and its cell markers such as CCR6 or CD3 was performed. The ratio of IL-17-positive cells was independent of disease activity, and the percentage of IL-17+CCR6+- and IL-17+CD3+- cells was less than 10%. Then, we explored correlation between relative expression levels of TNF-alpha, IFN-gamma, and IL-17 mRNA. TNF-alpha expression levels were strongly correlated with IFN-gamma; however, no significant correlation was detected between TNF-alpha and IL-17. Correlation between IFN-gamma and IL-17 expression levels was also explored, but no significant correlation was detected.
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[Presentation] 関節リウマチ滑膜組織におけるIL-17、IFN-γ、TNF-αの発現と関節破壊制御のメカニズム2013
Author(s)
中島新, 青木保親, 園部正人, 寺島史明, 高橋宏, 齊藤雅彦, 谷口慎治, 山田学, 後藤憲一郎, 田原正道, 山中一, 玉井浩, 小林達也, 中川晃一
Organizer
第28回日本整形外科学会基礎学術集会
Place of Presentation
幕張メッセ(千葉県)
Year and Date
2013-10-17
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[Presentation] 関節リウマチ患者における血中酸化ストレスの臨床的意義と滑膜線維芽細胞における活性酸素種(ROS)産生2013
Author(s)
中島新, 青木保親, 園部正人, 寺島史明, 高橋宏, 齊藤雅彦, 谷口慎治, 山田学, 後藤憲一郎, 田原正道, 山中一, 玉井浩, 小林達也, 中川晃一
Organizer
第28回日本整形外科学会基礎学術集会
Place of Presentation
幕張メッセ(千葉県)
Year and Date
2013-10-17
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