2013 Fiscal Year Final Research Report
Investigation of characteristics of zinc transporter ZIP13 protein
| Project/Area Number |
23592239
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
FUKADA Toshiyuki 独立行政法人理化学研究所, 統合生命医科学研究センター, 上級研究員 (70373363)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 亜鉛 / 亜鉛トランスポーター / 亜鉛シグナル / 骨軟骨代謝 / 歯 / 皮膚 / 結合組織 / エーラス・ダンロス症候群 |
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| Research Abstract |
The zinc transporter protein ZIP13 plays critical roles in bone, tooth, and connective tissue development, and its dysfunction is responsible for the novel type of Ehlers-Danlos syndrome: Spondylocheirodysplastic form of Ehlers-Danlos syndrome (SCD-EDS). We have investigated the characteristics of human wild-type ZIP13 protein, and the pathogenic mechanism of SCD-EDS caused by mutant ZIP13 proteins. We found that ZIP13 protein is localized to Golgi and forms homo-dimer state (Bin, JBC 2011), and mutant ZIP13 proteins are degraded by proteasome pathway leading to imbalanced intracellular Zn homeostasis (submitted). Our findings suggest that physio-pathological mechanisms elicited by wild-type and mutant ZIP13 proteins.
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Research Products
(29 results)
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[Journal Article] The diabetes susceptible gene SLC30A8/ZnT8 regulates hepatic insulin clearance2013
Author(s)
Tamaki, M., Y. Fujitani, A. Hara, T. Uchida, Y. Tamura, K. Takeno, M. Kawaguchi, T. Watanabe, T. Ogihara, A. Fukunaka, T. Shimizu, T. Mita, A. Kanazawa, M. O. Imaizumi, T. Abe, H. Kiyonari, S. Hojyo, T. Fukada, T. Kawauchi, S. Nagamatsu, T. Hirano, R. Kawamori, H. Watada
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Journal Title
J . Clin. Invest
Volume: 123
Pages: 4513-4524
DOI
Peer Reviewed
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