Cerebral protective effects of estrogen and progesterone under sevoflurane or propofol anesthesia

2014 Fiscal Year Final Research Report

• Project/Area Number: 23592246
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Anesthesiology/Resuscitation studies
• Research Institution: University of Yamanashi
• Principal Investigator: ISHIYAMA Tadahiko 山梨大学, 総合研究部, 准教授 (90293448)
• Co-Investigator(Kenkyū-buntansha): SHIBUYA Kazuhiro 山梨大学, 総合研究部, 助教 (30402027) ; MASAMUNE Taishi 山梨大学, 総合研究部, 助教 (40324199) ; IWASHITA Hironobu 山梨大学, 総合研究部, 助教 (10232670) ; TERADA Yoshihide 山梨大学, 総合研究部, 助教 (80334861)
• Project Period (FY): 2011-04-28 – 2015-03-31
• Keywords: ｾﾎﾞﾌﾙﾗﾝ / プロポフォール / エストロゲン / プロゲステロン / クラニアルウインドウ / 脳虚血・再灌流

Outline of Final Research Achievements

We investigated the effects of estrogen and progesterone on cerebral pial microvessels in the nornal state and ischemia-reperfusion period under sevoflurane or propofol anesthesia.
By using bispectral index, optimal doses of sevoflurane and propofol were determined as 3.9％ and 100 mg/kg/hr, respectively.
In the normal stete, estrogen and progesterone at 10-11～10-5 mol/L did not influence cerebral pial vascular diameter under either sevoflurane or propofol anesthesia. In the ischemia-reperfusion period, estrogen and progesterone at 10-6 mol/L did not influence cerebral pial vascular diameter under either sevoflurane or propofol anesthesia.

Free Research Field

麻酔薬と脳微小循環