2013 Fiscal Year Final Research Report
elucidation of the molecular mechanisms about the protective effect of hydrogen against renal ischemia-reperfusion injury
| Project/Area Number |
23592258
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Nagasaki University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MAEKAWA Takuji 長崎大学病院, 麻酔科, 講師 (10336167)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 腎虚血再灌流 / 水素 / 腎臓 / 保護 |
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| Research Abstract |
Organ ischemia-reperfusion injury in a living body, greatly changed the life prognosis. The studies were conducted with a focus on the renal protective effect of hydrogen as an agent with the organ protective effects. Use the Wistar rat, anesthesia enforcement, make tracheal intubation, artificial respiration, after exposure to the kidney on both sides side abdominal incision, to clamp en bloc renal artery, renal vein, ureter. Ischemic time is 40 minutes. Administration of hydrogen was performed by dividing the low concentration and high concentration group. After that, I closed the wound. Blood samples were collected after 24 hours, and measured blood urea nitrogen, and creatinine. By hydrogen administration, increased blood urea nitrogen, creatinine can be suppressed has been found.
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