Mechanism of antidote effect of lipid emulsion on the systemic toxicity of local anesthetics

2014 Fiscal Year Final Research Report

• Project/Area Number: 23592261
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Anesthesiology/Resuscitation studies
• Research Institution: Osaka City University
• Principal Investigator: ODA Yutaka 大阪市立大学, 医学(系)研究科(研究院), 登録医 (70214145)
• Project Period (FY): 2011-04-28 – 2015-03-31
• Keywords: 局所麻酔薬 / 中枢神経毒性 / 心毒性 / 脂肪乳剤

Outline of Final Research Achievements

Lipid emulsion decreases the central nervous system and cardiovascular toxicity of bupivacaine and levobupivacaine, as shown by an increased plasma concentration at the onset of convulsions and hypotension, cardiac arrest in awake, spontaneously breathing rats. These results suggest that influx of local anesthetics into lipid layer formed in blood vessels is an important mechanism for their antidote effect reported as “lipid sink”. Recently published reports suggest that other mechanisms such as volume loading, direct inotropic action, stabilization of intracellular calcium concentration and recovery of energy supply to cardiac muscle by increased metabolism of fatty acid are involved in the effect of lipid emulsion on cardiovascular toxicity induced by local anesthetics.

Free Research Field

麻酔科学