2013 Fiscal Year Final Research Report
Postoperative impairment of cognitive function in rats: A possible role of preoperative restraint stress induced microglial activation
Project/Area Number |
23592273
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Anesthesiology/Resuscitation studies
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Research Institution | University of Tsukuba |
Principal Investigator |
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Project Period (FY) |
2011 – 2013
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Keywords | 高次機能障害 / 拘禁ストレス / 手術 / spatial working memory / マイクログリア / IL-1β |
Research Abstract |
This study was conducted to evaluate the effect of preoperative 2 hrs restraint stress on microglial activation, an expression of interleukin-1beta in hippocampus and spatial working memory after surgery in adult and aged rats. Spatial working memory was affected after surgery in a 6-8 months adult rat undergoing preoperative 2 hrs restraint stress. In a 18-20 months aged rat, surgery itself induced postoperative impairment of spatial working memory. However, the impairment continued even on the 14 postoperative days in an aged rat undergoing preoperative 2 hrs restraint stress. Those were associated with microglial activation and an increased expression of interleukin-1beta on neuron in hippocampus.
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