2013 Fiscal Year Final Research Report
Analgesic mechanisms of gabapentinoids in spinal cord dorsal horn
| Project/Area Number |
23592277
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Niigata University |
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Principal Investigator |
BABA Hiroshi 新潟大学, 医歯学系, 教授 (00262436)
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| Project Period (FY) |
2011 – 2013
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| Keywords | プレガバリン / ガバペンチン / 一次求心性線維 / グルタミン酸 / 電位依存性カルシウムチャネル / シナプス前抑制 / 脊髄スライス / カルシウムイメージング |
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| Research Abstract |
We investigated the effects of gabapentinoids (pregabalin and gabapentin) on glutamatergic synaptic transmission in the spinal cord dorsal horn.Whole cell patch clamp recordings were made from superficial dorsal horn neurons of spinal cord slice with attached dorsal root. Gabapentinoids did not decrease the amplitude of monosynaptic excitatory synaptic currents evoked by dorsal root stimulations. These result suggest that gabapentinoids do not inhibit glutamate release from primary afferent terminals. The inhibition of voltage-gated calcium channels may not be a main analgesic mechanism of these gabapentinoid drugs.
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