2013 Fiscal Year Final Research Report
analgesic mechanisms of ketamine on neuropathic pain
| Project/Area Number |
23592279
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Niigata University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
IKOMA Miho 新潟大学, 医歯学系, 特任准教授 (30432082)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 神経障害性疼痛 / ケタミン / 脊髄後角 |
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| Research Abstract |
In clinically, very low dose ketamine intravenous infusion reduced the pain dramatically some of the neuropathic pain cases. We investigated the effects of NMDA receptor antagonist, ketamine, on noxious synaptic transmission in the substantia gelatinosa (SG) with the whole cell patch-clamp technique. In the neuropathic pain model rat spinal cord, percentage of neurons with polysynaptic A-delta fiber EPSCs increased to over 90 % of the sampled population.
Moreover, this polysynaptic EPSC was inhibited by ketamine. A similar result was provided in the in-vivo patch clamp recordings. Therefore, it was revealed that the NMDA receptor strongly participated in alternation of synaptic response on the neuropathic pain model rat spinal cord.
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Research Products
(5 results)
