2013 Fiscal Year Final Research Report
Can microdialysis monitor myocardial interstitial apoptotic markers evoked by ischemia-reperfusion?
| Project/Area Number |
23592285
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Shiga University of Medical Science |
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Principal Investigator |
YAMAZAKI TOJI 滋賀医科大学, 医学部, 非常勤講師 (20116122)
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| Co-Investigator(Kenkyū-buntansha) |
KITAGAWA Hirotoshi 滋賀医科大学, 医学部, 教授 (50252391)
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| Project Period (FY) |
2011 – 2013
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| Keywords | マイクロダイアリシス / アポトーシス / オンコーシス / 心筋虚血再灌流傷害 / チトクロムC / ミオグロビン |
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| Research Abstract |
The present study describes a measurement of the cell necrotic and apoptotic markers found in the myocardial interstitial space using cardiac microdialysis technique. The dialysate myoglobin (cardiac necrosis marker) levels elevated during coronary occlusion and reperfusion, however the dialysate cytochrome C (apoptosis marker) levels elevated during reperfusion. Therefore, cardiac ischemic injury evoked necrosis and reperfusion injury enhances both necrosis and apoptosis. This monitoring system might provide a new possibility for monitoring cardiac necrosis and apoptosis evoked by ischemia-reperfusion.
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