2013 Fiscal Year Final Research Report
Study on protection by Nrf2 activation against acute lung injury
| Project/Area Number |
23592288
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Tottori University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MATSURA Tatsuya 鳥取大学, 医学部, 教授 (00199746)
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| Project Period (FY) |
2011 – 2013
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| Keywords | Nrf2 / 急性肺傷害 / ポリフェノール / エンドトキシン / マクロファージ |
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| Research Abstract |
In the present study, we investigated whether Nrf2 activation suppresses macrophage activation as well as acute lung injury in mice induced by lipopolysaccharide (LPS). Hydroquinone and curucumin inhibited the production of nitric oxide in RAW macrophage cells treated with LPS via activation of Nrf2. When mice were treated with low dose of LPS followed by its lethal dose, all mice survived via marked induction of Nrf2 after treatment with lethal dose of LPS.
It was suggested that Nrf2 activation could protect against LPS-induced acute lung injury in mice.
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