Is angiogenesis in regenerative medicine influenced by perioperative management methods? -effect of hyperglycemia-

2013 Fiscal Year Final Research Report

• Project/Area Number: 23592292
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Anesthesiology/Resuscitation studies
• Research Institution: The University of Tokushima
• Principal Investigator: KAWAHITO Shinji 徳島大学, 大学病院, 講師 (60284296)
• Co-Investigator(Kenkyū-buntansha): KITAHATA Hiroshi 徳島大学, 大学院ヘルスバイオサイエンス研究部, 教授 (60161486) ; MATSUHISA Munehide 徳島大学, 糖尿病臨床・研究開発センター, 特任教授 (60362737) ; TAKAISHI Kazumi 徳島大学, 大学院ヘルスバイオサイエンス研究部, 助教 (20325286)
• Project Period (FY): 2011 – 2013
• Keywords: 再生医療 / 血管新生 / 周術期管理法 / 血糖管理

Research Abstract

We examined the influence of perioperative management methods, especially glycemic control on angiogenesis in animal experiments, clinical studies, and basic experiments using cultured cells. Animal experiments and clinical studies revealed the effect on angiogenesis of acute hyperglycemia should be less, however, basic experiments using cultured cells indicated hyperglycemia tended to inhibit angiogenesis. It is hoped that a new indicator of the perioperative administration is established by the influence of glycemic control which gives it to angiogenesis being elucidated.

Research Products

• [Journal Article] J wave after induction of anaesthesia using propofol in a patient with early repolarization (2014)
  • Author(s): Takaishi K, Kawahito S, Tomioka S, Eguchi S, Kitahata H
  • Journal Title: Anaesthesia Volume: 69 Pages: 170-175
  • Peer Reviewed
• [Journal Article] Surgical indication and perioperative management of severe anorexia nervosa (2014)
  • Author(s): Hirose K, Hirose M, Tanaka K, Kawahito S, Tamaki T, Oshita S
  • Journal Title: Br J Anaesth Volume: 112 Pages: 246-254
  • Peer Reviewed
• [Journal Article] The supine to prone postural change induces modification of endotracheal tube cuff pressure accompanied by the tube displacement (2013)
  • Author(s): Minonishi T, Kinoshita H, Hirayama M, Kawahito S, Azma T, Hatakeyama N, Fujiwara Y
  • Journal Title: J Clin Anesth Volume: 23 Pages: 28-31
  • Peer Reviewed
• [Journal Article] Local anesthetics inhibit nitric oxide production and L-arginine uptake in cultured bovine aortic endothelial cells (2013)
  • Author(s): Takaishi K, Kawahito S, Kitahata H
  • Journal Title: Eur J Phamacol Volume: 704 Pages: 58-63
  • Peer Reviewed
• [Journal Article] Usefulness of continuous blood glucose monitoring and control for patients undergoing liver transplantation (2013)
  • Author(s): Okada T, Kawahito S, Mita N, Matsuhisa M, Kitahata H, Shimada M, Oshita S
  • Journal Title: J Med Invest Volume: 60 Pages: 205-212
  • Peer Reviewed
• [Journal Article] Recent less-invasive circulatory monitoring during renal transplantation (2013)
  • Author(s): Soga T, Kawahito S, Oi R, Kakuta N, Katayama T, Wakamatsu N, Takaishi K, Yamaguchi K, Izaki H, Kanayama H, Kitahata H, Oshita S
  • Journal Title: J Med Invest Volume: 60 Pages: 159-163
  • Peer Reviewed
• [Journal Article] Usefulness of central venous oxygen saturation monitoring during bidirectional Glenn shunt (2013)
  • Author(s): Kakuta N, Kawahito S, Mita N, Kambe N, Kasai A, Wakamatsu N, Katayama T, Soga T, Tada F, Kitaichi T, Kitagawa T, Kitahata H
  • Journal Title: J Med Invest Volume: 60 Pages: 272-275
  • Peer Reviewed
• [Journal Article] Novel blood sampling method of an artificial endocrine pancreas via the cardiopulmonary bypass (2013)
  • Author(s): Kawahito S, Higuchi S, Mita N, Kitagawa T, Kitahata H
  • Journal Title: J Artif Organs Volume: 16 Pages: 508-509
  • Peer Reviewed
• [Journal Article] Role of neuronal nitric oxide synthase, oxidative stress and propofol in N-methyl-D-aspartate-induced dilation of cerebral arterioles (2012)
  • Author(s): Hama-Tomioka K, Kinoshita H, Nakahata K, Kondo T, Azma T, Kawahito S, Hatakeyama N, Matsuda N
  • Journal Title: Br J Anaesth Volume: 108 Pages: 21–29
  • Peer Reviewed
• [Journal Article] Dexmedetomidine directly inhibits vascular ATP-sensitive potassium channels (2012)
  • Author(s): Kawano T, Yamazaki F, Chi H, Kawahito S, Eguchi S
  • Journal Title: Life Sci Volume: 90 Pages: 272-277
  • Peer Reviewed
• [Journal Article] Isoflurane pre-treatment preserves ATP-sensitive K+ channel function in the human artery exposed to oxidative stress caused by high glucose (2012)
  • Author(s): Kinoshita H, Matsuda N, Iranami H, Ogawa K, Hatakeyama N, Azma T, Kawahito S, Yamazaki M
  • Journal Title: Anesth Analg Volume: 115 Pages: 54-61
  • Peer Reviewed
• [Journal Article] Molecular mechanisms of the inhibitory effects of clonidine on vascular adenosine triphosphate- sensitive potassium channels (2011)
  • Author(s): Kawahito S, Kawano T, Kitahata H, Oto J, Takahashi A, Takaishi K, Harada N, Nakagawa T, Kinoshita H, Azma T, Nakaya Y, Oshita S
  • Journal Title: Anesth Analg Volume: 113 Pages: 1374-1380
  • Peer Reviewed
• [Journal Article] Anaesthesia for a patient with paraneoplastic limbic encephalitis with ovarian teratoma : relationship to anti-N-methyl-D- aspartate receptor antibodies (2011)
  • Author(s): Kawano H, Hamaguchi E, Kawahito S, Tsutumi YM, Tanaka K, Kitahata H, Oshita S
  • Journal Title: Anaesthesia Volume: 66 Pages: 515-518
  • Peer Reviewed
• [Presentation] Continuous blood glucose monitoring during cardiopulmonary bypass for children (2013)
  • Author(s): Mita N, Kawahito S, Kakuta N, Kume K, Takaishi K, Kitahata H
  • Organizer: American Society of Anesthesiologists (ASA) Annual Meeting
  • Place of Presentation: San Francisco, CA, USA
  • Year and Date: 2013-10-13
• [Presentation] Intraoperative application of the artificial endocrine pancreas (2013)
  • Author(s): Mita N, Kawahito S, Kakuta N, Kume K, Takaishi K, Kitahata H
  • Organizer: American Society of Anesthesiologists (ASA) Annual Meeting
  • Place of Presentation: San Francisco, CA, USA
  • Year and Date: 2013-10-12
• [Presentation] The effects of intravenous anesthetics on in vitro angiogenesis and cell proliferation (2013)
  • Author(s): Takaishi K, Kawahito S, Mita N, Tatsuishi T, Eguchi S, Kitahata H
  • Organizer: European Society of Anesthesiology (ESA) Annual Meeting
  • Place of Presentation: Barcelona, Spain
  • Year and Date: 2013-06-02
• [Presentation] next-generation artificial endocrine pancreas (2012)
  • Author(s): Mita N, Kawahito S, Takaishi K, Kitahata H, Oshita S
  • Organizer: American Society of Anesthesiologists (ASA) Annual Meeting
  • Place of Presentation: Washington DC, USA
  • Year and Date: 2012-10-16
• [Presentation] The effects of intravenous anesthetics on the release of vascular endothelial growth factor and angiogenesis (2012)
  • Author(s): Takaishi K, Kawahito S, Nakamura D, Tatsuishi T, Eguchi S, Kitahata H
  • Organizer: European Society of Anesthesiology (ESA) Annual Meeting
  • Place of Presentation: Paris, France
  • Year and Date: 2012-06-10
• [Presentation] Continuous blood glucose monitoring and control for patients undergoing hepatic resection (2011)
  • Author(s): Kawahito S, Kitahata H, Okada T, Hirose K, Oshita S
  • Organizer: American Society of Anesthesiologists (ASA) Annual Meeting
  • Place of Presentation: Chicago, USA
  • Year and Date: 2011-10-15
• [Book] III心血管作動薬の使用法,4.カルシウム拮抗薬, 5.カリウムチャネル開口薬-For Professional Anesthesiologists-心血管作動薬 (2013)
  • Author(s): 廣瀬佳代、川人伸次
  • Total Pages: 348 (160-169),348 (170-178)
  • Publisher: 土田英昭(編),克誠堂出版,東京
• [Book] 花崎和弘(編)臨床に役立つ最新血糖管理マニュアル,肝移植の血糖管理 (2012)
  • Author(s): 川人伸次,島田光生,北畑洋
  • Total Pages: 271 (145-151)
  • Publisher: 医学図書出版,東京
• [Book] Chapter 21. Contrast Echo Method. In : Omoto R, Konstadt S, Orihashi K (ed), Transesophageal Echocardiography 2nd Edittion (2012)
  • Author(s): Kitahata H, Kawahito S
  • Total Pages: 447 (354–369)
  • Publisher: Shindan-to- Chiryo Sya, Tokyo, JAPAN
• [Book] 岡本浩嗣,外須美夫(編)経食道心エコー撮り方,診かたの基本とコツ改訂新版,第1章基礎・準備編1.プローブの選択と安全な挿入法 (2011)
  • Author(s): 川人伸次,北畑洋
  • Total Pages: 147(12–18)
  • Publisher: 羊土社,東京
• [Remarks]
  • URL: http://www.tokushima-u.ac.jp/med/culture/masui_totsu/ikyoku/