2013 Fiscal Year Final Research Report
Effects of volatile anesthetics on ischemia-reperfusion injury in Non-alcoholic steatohepatitis rats: interaction with anti-diabetic drugs
| Project/Area Number |
23592297
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Nagasaki University |
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Principal Investigator |
CHO Sungsam 長崎大学, 大学病院, 講師 (90325655)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 非アルコール性脂肪肝炎 / 虚血再灌流傷害 / 肝臓 / 揮発性麻酔薬 / チアゾリン薬 / インクレチン |
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| Research Abstract |
Volatile anesthetic sevoflurane, thiazolidinedione pioglitazone, and glucagon-like peptide 1 liraglutide administered before ischemia would prevent ischemia-reperfusion-induced liver damage, apoptosis, or survival rate. Non-alcoholic steatohepatitis (NASH) rats resulted in more ischemia-reperfusion-induced liver damage and decreased a survival rate as compared with normal rats. And the protective effects of sevoflurane, pioglitazone, and liraglutide have been inhibited in NASH rats. The combination sevoflurane and pioglitazone administered before ischemia would prevent ischemia-reperfusion-induced liver damage, apoptosis, or survival rate in NASH rats. This combination has better protection than sevoflurane, pioglitazone, and liraglutide alone in NASH rats.
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