2013 Fiscal Year Final Research Report
A new strategy for adrenal insufficiency in septic shock: a new antioxdant ETS-GS
| Project/Area Number |
23592300
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Oita University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2013
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| Keywords | 敗血症 / 酸化ストレス / ビタミンC / 電子スピン共鳴 / 副腎不全 / ETS-GS |
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| Research Abstract |
In the septic rat model administered lipopolysaccharide(LPS), we established the method to measure in real time serum vitamin C levels by using an electron spin resonance spectrometer. Twenty four hours after high dose LPS, serum vitamin C decresed remarkably and the inflammatory response increased.
The new antioxidant, ETS-GS which has very strong antiinflammatory and antioxidant effects tended to inhibit serum vitamin C loss and the infllammatory response. The hormones of pituitary and adrenal, however, didn't increase significantly. Therefore, I could not figure out the relationship between the ETS-GS and the hypothalamus-pituitary-adrenal axis.
In the future, I will plan to use the SMP30 knockout mouse which cannot synthesize vitamin C like human and continue this study.
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