2013 Fiscal Year Final Research Report
calcium sensitization in pulmoary hypertension
| Project/Area Number |
23592304
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Yokohama City University |
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Principal Investigator |
MIZUNO Yusuke 横浜市立大学, 医学部, 講師 (80433192)
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| Co-Investigator(Kenkyū-buntansha) |
KAWAKAMI Hiromasa 横浜市立大学, 医学部, 助教 (90407958)
WATANABE Itaru 横浜市立大学, 医学研究科, 客員教授 (20534142)
BABA Yasuko 横浜市立大学, 市民総合医療センター, 講 師 (80453041)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 肺高血圧症 / MLCK / リン酸化 / desensitization |
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| Research Abstract |
In this study, we found the involvement of imparied calcium desensitization mechanism of MLCK by phosphorylation of MLCK in pulmoanry hypertension in rats. It is well known that calcium sensitization occured during vascular contraction and in hyper-vasocontractile diseases. However, calcium desensitization mechanism in vasucura diseases is little known. The understanding of the desensitization mechanism may provide novel therapy for pulmonary hypertension.
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