2013 Fiscal Year Final Research Report
Behavioral study on potassium channel openers as a novel remedy for neuropathic pain.
| Project/Area Number |
23592316
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Anesthesiology/Resuscitation studies
|
|---|
| Research Institution | University of Occupational and Environmental Health, Japan |
|---|
Principal Investigator |
HARA Koji 産業医科大学, 医学部, 講師 (20331001)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
HARANISHI Yasunori 産業医科大学, 医学部, 講師 (90449942)
KATAOKA Kazunori 産業医科大学, 医学部, 助教 (70441839)
NAKAMURA Motohiro 産業医科大学, 医学部, 助教 (30461578)
SATA Takeyoshi 産業医科大学, 医学部, 教授 (60128030)
|
|---|
| Project Period (FY) |
2011 – 2013
|
| Keywords | 神経障害性疼痛 / 鎮痛薬 / 行動薬理学 |
|---|
| Research Abstract |
The analgesic effects of three groups of potassium (K) channel openers were examined using a rat neuropathic pain model. Several K channel openers were administered intrathecally or intracerebroventricularly to examine the central effects on mechanical, thermal, and cold hyperalgesia induced by chronic constriction injury to the sciatic nerve. Spinally- and supraspinally-applied calcium-activated potassium channel (Kca) openers attenuated mechanical and cold hyperalgesia. On the other hand, the openers of voltage-dependent K channel and two-pore-domain K channel had no effect on the hyperalgesia displayed in the rats. The Kca channel openers may exert antihyperalgesic effects both in the spinal cord and the brain.
|
