Analysis of anoikis resistance acquisition, and studies of prognostic predictor and therapeutic target in renal cell carcinoma

2013 Fiscal Year Final Research Report

• Project/Area Number: 23592337
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Urology
• Research Institution: Nagasaki University
• Principal Investigator: OHBA Kojiro 長崎大学, 医歯(薬)学総合研究科, 助教 (20593825)
• Co-Investigator(Kenkyū-buntansha): MIYATA Yasuyoshi 長崎大学, 大学院医歯薬学総合研究科, 准教授 (60380888)
• Co-Investigator(Renkei-kenkyūsha): MATSUO Tomohiro 長崎大学, 大学院医歯薬学総合研究科, 助教 (60622024)
• Project Period (FY): 2011 – 2013
• Keywords: アノイキス / 腎細胞癌 / TWIST / Fer

Research Abstract

We have determined the pathological roles and clinical significance of Twist that was the transcription factor (in the process of the examination), although the mechanism of the anoikis resistance acquisition in the renal cell carcinoma (RCC) is complex and not interpretable. Twist expression is speculated to play important roles in the gain of malignant potential and malignant aggressiveness, including cancer cell invasion and metastasis, and is associated with cause- specific survival in patients with RCC. Multi-variate analyses showed that the up-regulation of Twist influences tumor progression in patients with RCC via the acceleration of MMP2 expression, and the recruitment of macrophages. We suggest that Twist is useful predictor and potential therapeutic target for the treatment of RCC.

Research Products

• [Journal Article] High expression of Twist is associated with tumor aggressiveness and poor prognosis in patients with renal cell carcinoma : its correlation with cell proliferation, angiogenesis, matrix metalloproteinase-2 expression, and macrophage recruitment (2014)
  • Author(s): Ohba K, Miyata Y, Matsuo T, Asai A, Mitsunari K, Shida Y, Kanda S, Sakai H
  • Journal Title: Int J Clin Exp Pathol Volume: (in press)
  • Peer Reviewed
• [Journal Article] 泌尿器系癌におけるEプロスタノイドレセプターとその役割 (2013)
  • Author(s): 大庭,康司郎,宮田,康好,酒井,英樹
  • Journal Title: 泌尿器科紀要 Volume: 59(2) Pages: 83-89
  • Peer Reviewed
• [Journal Article] Feline sarcoma-related protein expression correlates with malignant aggressiveness and poor prognosis in renal cell carcinoma (2013)
  • Author(s): Miyata Y, Kanda S, Sakai H, Greer P
  • Journal Title: Cancer Sci Volume: 104 Pages: 681-686
  • Peer Reviewed
• [Journal Article] Pathological significance and prognostic value of phosphorylated cortactin expression in patients with sarcomatoid renal cell carcinoma (2011)
  • Author(s): Matsuo T, Miyata Y, Watanabe S, Sagara Y, Ohba K, Hayashi T, Kanda S, Sakai H
  • Journal Title: Urology Volume: 78 Pages: 476e9-e16
  • Peer Reviewed
• [Journal Article] Fer is proliferative regulator of renal cancer cells and its expression was associated with pathological features and survival in patients with renal cell carcinoma (2011)
  • Author(s): Miyata Y, Kanda S, Sakai H, Greer P
  • Journal Title: J Urol Volume: 185 Pages: e154
  • Peer Reviewed
• [Presentation] 低グルコース環境下での腎癌細胞のアノイキス抵抗性の獲得についての検討 (2014)
  • Author(s): 松尾朋博
  • Organizer: 第23回泌尿器科分子・細胞研究会
  • Year and Date: 20140314-15
• [Presentation] Clinical significance and predictive value of prostaglandin E2 receptor (EPR) 1-4 in patients with renal cell carcinoma (2011)
  • Author(s): Ohba K
  • Organizer: 第63回日本泌尿器科学会西日本総会ヤングウロロジーリサーチコンテスト
  • Place of Presentation: 久留米市
  • Year and Date: 20111110-12
• [Presentation] Fer is proliferative regulator of renal cancer cells and its expression was associated with pathological features and survival in patients with renal cell carcinoma (2011)
  • Author(s): Miyata Y
  • Organizer: AUA Annual Meeting
  • Place of Presentation: Washington, DC
  • Year and Date: 20110514-19
• [Presentation] 腎癌組織におけるprostaglandin E2 receptor (EPR) 1-4の臨床的意義と予後との関連についての検討 (2011)
  • Author(s): 大庭康司郎
  • Organizer: 第99回日本泌尿器科学会総会
  • Place of Presentation: 名古屋市
  • Year and Date: 20110421-24