2013 Fiscal Year Final Research Report
Analysis of Dkk-1 function in castrate-resistant prostate cancer
| Project/Area Number |
23592339
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Kumamoto University |
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Principal Investigator |
KAWANO Yoshiaki 熊本大学, 大学院生命科学研究部, 助教 (30593793)
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| Co-Investigator(Kenkyū-buntansha) |
ETO Masatoshi 熊本大学, 生命科学研究部, 教授 (90315078)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 前立腺癌 |
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| Research Abstract |
Amongst prostate cancer cell lines, we found Dkk1 was expressed in the culture supernatant of castrate-resistant PC-3 cells by western blot. We established LNCaP cell line inducibly expressing Dkk1 in a tetracycline dependent manner. However, those cells did not exhibit castration resistance in vitro by inducible Dkk1 expression. On the other hand, invasion of PC-3 in boyden chamber was significantly inhibited by Dkk1 knockdown by siRNA. These results suggest that Dkk1 expression does not directly contribute to acquisition of castration resistance but is rather involved in invasiveness of castrate resistant prostate cancer cells.
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Author(s)
Hidetoshi Nitta, Yoshihiro Wada, Yoshiaki Kawano, Yoji Murakami, Atsushi Irie, Keisuke Taniguchi, Ken Kikuchi, Gen Yamada, Kentaro Suzuki, Jiro Honda, Masayo Wilson-Morifuji, Norie Araki, Masatoshi Eto, Hideo Baba and Takahisa Imamura
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Journal Title
J Med Case Rep
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