2013 Fiscal Year Final Research Report
Development of new therapy using novel chimeric oncolytic adenoviruse vector for intractable bladder cancer.
| Project/Area Number |
23592354
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Hyogo Medical University |
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Principal Investigator |
GOTOH Akinobu 兵庫医科大学, 医学部, 教授 (70283885)
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| Co-Investigator(Kenkyū-buntansha) |
NAGAYA Hisao 兵庫医科大学, 医学部, 助教 (60464343)
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| Co-Investigator(Renkei-kenkyūsha) |
TAGAWA Masatoshi 千葉県がんセンター, 病理研究部, 部長 (20171572)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 膀胱癌 / アデノウイルスベクター / 遺伝子治療 |
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| Research Abstract |
In this study, we examined whether the fiber knob substituted adenovirus vector enhance the therapeutic effect of gene therapy for human bladder cancer which do not have a significant effect on therapeutic outcome of adenovirus gene therapy. Our data showed the novel fiber knob substituted adenovirus vector, Ad5F35/MK, is more useful for the gene therapy of bladder cancer than the non fiber knob substituted Ad5/MK is for human bladder cancer in vitro and in vivo.
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