2013 Fiscal Year Final Research Report
The basic research for the novel treatment for under active bladder -focusing on the construction of troponin system in smooth muscle-
| Project/Area Number |
23592371
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Kyushu University |
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Principal Investigator |
KAJIOKA Shunichi 九州大学, 医学(系)研究科(研究院), 研究員 (90274472)
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| Co-Investigator(Kenkyū-buntansha) |
SEKI Narihito 九州大学, 大学院医学研究院, 准教授 (90294941)
TAKAHASHI Fumi 九州大学, 大学院医学研究院, 助教 (50274436)
ITO Shinichi 九州大学, 大学院医学研究院, 助教 (40291520)
YONEMITSU Yoshikazu 九州大学, 大学院薬学研究院, 客員教授 (40315065)
NAKAYAMA Shinsuke 名古屋大学, 大学院医学研究科, 准教授 (30192230)
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| Project Period (FY) |
2011 – 2013
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| Keywords | トロポニン / 平滑筋 / 排尿機能 / 低活動膀胱 / 膀胱排尿筋 |
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| Research Abstract |
It has been generally accepted that in smooth muscle contraction, MLCK system but not troponin system is dominant. However, we found cardiac troponin T (cTnT) in urinary bladder smooth muscle.
The following present study was thus designed in order to clarify troponin subunits in smooth muscle and to explore the possibility for clinical treatment using detrusor smooth muscle. Troponin is composed of 3 subunits (T, I, and C), and categorized into 3 groups (cardiac, slow skeletal muscle, fast skeletal muscle). We examined all troponin subunits and clarified the expression of not only all types of TnT but also slow skeletal muscle type of troponin I in human detrusor. Further, dominant expression of their genes were recognized compared to other smooth muscle organs. The smooth muscle specific protein, calponin and caldesmon were also expressed at protein level suggesting novel contraction system combined with troponin subunits and their protein.
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[Journal Article] Endogenous cardiac troponin T modulates Ca(2+)-mediated smooth muscle contraction2012
Author(s)
Kajioka S, Takahashi-Yanaga F, Shahab N, Onimaru M, Matsuda M, Takahashi R, Asano H, Morita H, Morimoto S, Yonemitsu Y, Hayashi M, Seki N, Sasaguri T, Hirata M, Nakayama S, Naito S
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Journal Title
Sci Rep
Volume: 2
Pages: 979
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[Journal Article] Dual signaling pathways of arterial constriction by extracellular uridine 5'-triphosphate in the rat2011
Author(s)
Sugihara M, Morita H, Matsuda M, Umebayashi H, Kajioka S, Ito S, Nishida M, Inoue R, Futatsuki T, Yamazaki J, Mori Y, Inoue R, Ito Y, Abe K, Hirata M
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Journal Title
J Pharmacol Sci
Volume: 115(3)
Pages: 293-308
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