2013 Fiscal Year Final Research Report
The effect of afferent activation from prostate on rat bladder overactivity
| Project/Area Number |
23592373
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Fukushima Medical University |
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Principal Investigator |
AIKAWA Ken 福島県立医科大学, 医学部, 准教授 (80295419)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 前立腺 / 過活動膀胱 / 求心性刺激 / c-fos / アンジオテンシンII |
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| Research Abstract |
The present study tried to determine whether the increased afferent activation from prostate is the pathophysiology of overactive bladder in males. Angiotensin II increased the discharge of noradrenaline from prostate. In addition, angiotensin II increased the afferent activity of prostate as indicated by c-fos expression in L6. Furthermore, continuous cystometry demonstrated that angiotensin II shortened bladder contraction intervals. Taken together, this study suggests that the afferent activity of prostate involves overactive bladder and angiotensin II type 1 receptor antagonists may be therapeutic medicine.
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