2013 Fiscal Year Final Research Report
Mechanism of deteriorated recovery of cavernous nerve function with aging.
| Project/Area Number |
23592381
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Urology
|
|---|
| Research Institution | Juntendo University (2013)
Teikyo University (2011-2012) |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2011 – 2013
|
| Keywords | 再生医学 / アンドロロジー / 海綿体神経 / 加齢 |
|---|
| Research Abstract |
The cohabitation with female rats w/ rotation induces the recovery from ED following CN injury. We established the rehabilitation animal model using the 'Coolidge effect.' Preoperative administration of Eviprostat improved the erectile function following cavernous nerve injury, which implicated that the anti-inflammatory and anti-oxidative effect induces the early recovery of erectile function following cavernous nerve injury. Higher age has a negative impact on the nNOS-positive ganglionic neuron count in human. This result will lead to the rationale why older people show the poor outcome in their recovery of erection following radical prostatectomy.
|
