Endothelial chimerism after ABO-incompatible kidney transplantation

2014 Fiscal Year Final Research Report

• Project/Area Number: 23592384
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Urology
• Research Institution: Tokyo Women's Medical University
• Principal Investigator: ISHIDA Hideki 東京女子医科大学, 医学部, 臨床教授 (60246543)
• Co-Investigator(Kenkyū-buntansha): TANABE Kazunari 東京女子医科大学, 医学部, 教授 (80188359)
• Project Period (FY): 2011-04-28 – 2015-03-31
• Keywords: 腎移植 / 血液型不適合 / 抗体 / カイメリズム

Outline of Final Research Achievements

Endothelial chimerism in transplanted organs can be defined as the presence of recipient-derived endothelial cells in the donor organ. First, we investigated the presence of chimerism in renal allografts of ABO-incompatible kidney transplantation recipients. Second, we analyzed the association between chimerism and the clinical course. We investigated the presence of chimerism in renal allografts of ABO-incompatible kidney transplantation recipients by immunohistochemical detection of blood type A and B antigens and assessed the association between chimerism and the clinical course. Twelve of the 49 patients (24.5%) exhibited endothelium chimerism in a biopsy sample. Among the 12 patients with endothelium chimerism, 7 patients ( 59%) had acute and chronic active antibody-mediated rejection. The graft survival rate in the chimerism group was significantly lower than that in the no-chimerism group. Endothelial chimerism appears to be a hallmark of vigorous immune or non-immune responses.

Free Research Field

腎移植