2013 Fiscal Year Final Research Report
The elucidation of functional roles of GABA receptor during spermatogenesis process
| Project/Area Number |
23592387
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Osaka Medical College |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MORI Yoshiaki 関西福祉科学大学, 保健医療学部, 教授 (70268192)
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| Project Period (FY) |
2011 – 2013
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| Keywords | GABAA受容体 / 精子形成過程 / 核内移行 |
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| Research Abstract |
We investigated whether the alpha 1 subunit of GABAA receptor which was cell membranous receptor would be translocated into the nucleus during spermatogenesis process using Western blotting and immunoelectron microscopy. These findings suggested that the alpha 1 subunit which was translocated into the nucleus might function as a gene transcription factor in the area of condensed chromatin during the maturation of germ cells. Furthermore, it was thought that the nuclear translocation of the alpha 1 subunit received some kind of genetic control in the transfection experiment of the alpha 1 subunit.
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