Prediction, prevention and treatment of preeclampsia by measuring and controlling angiogenic factors

2013 Fiscal Year Final Research Report

• Project/Area Number: 23592396
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Obstetrics and gynecology
• Research Institution: The University of Tokyo
• Principal Investigator: KOGA Kaori 東京大学, 医学部附属病院, 講師 (10396723)
• Project Period (FY): 2011 – 2013
• Keywords: 血管新生因子

Research Abstract

Angiogenic modulator, such as sFlt1 produced by poorly invaded placenta, is known to be involved in the pathogenesis of preeclampsia. This study demonstrated that 1) thrombin, a major factor produced during the clot formation, induced sFlt1 production in trophoblasts, and 2) measuring serum sFlt1 and placental growth factor (PlGF) can predict the onset of preeclampsia.

Research Products

• [Journal Article] Galectin-7 serum levels are altered prior to the onset of pre-eclampsia (2014)
  • Author(s): Menkhorst E, Koga K, Van Sinderen M, Dimitriadis E
  • Journal Title: Placenta Volume: 35(4) Pages: 281-5
• [Journal Article] Thrombin enhances soluble Fms-like tyrosine kinase 1 expression in trophoblasts; possible involvement in the pathogenesis of preeclampsia (2012)
  • Author(s): Zhao Y, Koga K, Osuga Y, Nagai M, Izumi G, Takamura M, Harada M, Hirota Y, Yoshino O, Taketani Y
  • Journal Title: Fertil Steril Volume: 98(4) Pages: 917-21
• [Journal Article] High mobility group box 1 (HMGB1) levels in the placenta and in serum in preeclampsia (2011)
  • Author(s): Wang B, Koga K, Osuga Y, Hirata T, Saito A, Yoshino O, Hirota Y, Harada M, Takemura Y, Fujii T, Taketani Y
  • Journal Title: Am J Reprod Immunol Volume: 66(2) Pages: 143-8
• [Journal Article] Toll-like Receptors at the Maternal-Fetal Interface in Normal Pregnancy and Pregnancy Complications
  • Author(s): Koga K, Izumi G, Mor G, Fujii T, Osuga Y
  • Journal Title: Am J Reprod Immunol Volume: (in press)
• [Presentation] Angiogenic factors in Preeclampsia (2013)
  • Author(s): Kaori Koga
  • Organizer: Annual congress of International society for reproductive immunology
  • Place of Presentation: USA
  • Year and Date: 2013-05-01
• [Presentation] Prediction of PE study in Japan (2013)
  • Author(s): Kaori Koga
  • Organizer: 2nd Preeclampsia Early Adopters Meeting
  • Place of Presentation: Austria
  • Year and Date: 2013-04-01
• [Presentation] トロンビンは絨毛外栄養膜細胞の可溶型Fms様チロシンキナーゼ1の産生を増加させる (2011)
  • Author(s): 永井美和子、甲賀かをり, ら
  • Organizer: 日本妊娠高血圧学会学術集会
  • Place of Presentation: 金沢
  • Year and Date: 2011-12-01
• [Presentation] 妊娠高血圧症候群と血管新生抑制因子 (2011)
  • Author(s): 甲賀かをり
  • Organizer: 第19回日本胎盤学会学術集会シンポジウム
  • Place of Presentation: 東京
  • Year and Date: 2011-09-01
• [Presentation] 成因としての血管新生因子 (2011)
  • Author(s): 甲賀かをり
  • Organizer: 第21回腎と妊娠研究会ワークショップ
  • Place of Presentation: 埼玉
  • Year and Date: 2011-03-01