2013 Fiscal Year Final Research Report
Role of TIMP in reproductive medicine-infertility and preeclampsia in mouse model with implantation failure
| Project/Area Number |
23592401
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Osaka University |
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Principal Investigator |
TSUTSUI Tateki 大阪大学, 医学(系)研究科(研究院), 准教授 (00294075)
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| Co-Investigator(Kenkyū-buntansha) |
NAKAMURA Hitomi 大阪大学, 大学院医学系研究科, 助教 (80467571)
KUMASAWA Keiichi 大阪大学, 大学院医学系研究科, 助教 (90444546)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 生殖医学 / 妊娠高血圧症候群 / 着床不全 / TIMP / MMP / 不妊症 |
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| Research Abstract |
Preeclampsia is regarded as a pregnancy-specific syndrome of reduced organ perfusion. Although there's still no single theory that can account for all of the clinical symptoms in preeclampsia, the pathologic hallmark appears to be complete or partial failure of trophoblast invasion.
To assess the effect of tissue inhibitor of metalloproteinase 3 (TIMP3) which inhibits the activity of matrix metalloproteinases on pregnancy, we established a mouse model of a local and transient in vivo TIMP3 gene transfer system using Hemagglutinating virus of Japan envelope vector. Transient transfection of TIMP3 into the pregnant mouse uterine cavity on days 6.5 p.c. led to the raise of systolic blood pressure after 14.5 p.c. compared with a control mouse. We also observed the tendency of intrauterine growth restriction in the pups of TIMP3 gene transfer group compared with control group. We speculated that TIMP3 would play a pivotal role in the development of preeclampsia.
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