2013 Fiscal Year Final Research Report
Nuclear matrix associating factors, Satb, are novel regulators of murine placentation
| Project/Area Number |
23592405
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
FUKUSHIMA Kotaro 九州大学病院, 産科婦人科, 講師 (40304779)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 胎盤 / 栄養膜幹細胞 / 分化 / 転写因子 |
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| Research Abstract |
We identified novel regulators of trophoblast cell differentiation, Satb1 and Satb2. They had been known as nuclear matrix associating molecules. Satb1 and Satb2 are necessary to maintain rodent trophoblast cells at stem cell condition. We also discovered Eomes as a target gene of Satb1 and Satb2. Eomes is a well-known regulator necessary for maintenance of trophoblast stem cells. Therefore, Satb1 and Satb2 upregulate Eomes expression to keep trophoblast cells from differentiation. We published these results as a paper (Asanoma et al., 2012).
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[Journal Article] Inhibition of AHR transcription by NF1C is affected by a single nucleotide polymorphism, and is involved in suppression of human uterine endometrial cancer2013
Author(s)
Li D, Takao T, Tsunematsu R, Morokuma S, Fukushima K, Kobayashi H, Saito T, Furue M, Wake N, Asanoma K
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Journal Title
Oncogene
Volume: 32
Pages: 4950-4959
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