2013 Fiscal Year Final Research Report
Identification of cell-free placental mRNAs/microRNAs and their clinical significance
| Project/Area Number |
23592406
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Nagasaki University |
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Principal Investigator |
MIURA KIYONORI 長崎大学, 医歯(薬)学総合研究科, 准教授 (00363490)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 胎盤機能 / RNA / 母体血 |
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| Research Abstract |
1)Placenta-specific miRNA located on 19q13.42 in maternal plasma were identified. 2) Expression levels of placenta-specific miRNAs during 3rd trimester were twice or more than those during first trimester. 3)-1. In cases of monochorionic diamniotic twins, the measurement of cell-free placenta-specific miRNAs may be predictive markers for twin to twin transfusion syndrome (TTTS). 3)-2. Circulating levels of placenta-specific miRNAs was associated with the status of preeclampsia. 3)-3. Circulating levels of placenta-specific miRNAs was associated with fetal growth. 3)-4. The plasma CHM-miRNAs could be an additional follow-up marker for malignant changes of CHM. 4) The measurement of cell-free pregnancy-associated placenta-specific miRNAs levels in maternal plasma may reflect the pregnancy status related to placenta volume.
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[Journal Article] Predominantly placenta-expressed mRNAs in maternal plasma as predictive markers for twin-twin transfusion syndrome2014
Author(s)
Miura K, Higashijima A, Miura S, Mishima H, Yamasaki K, Abe S, Hasegawa Y, Kaneuchi M, Yoshida A, Kinoshita A, Yoshiura KI, Masuzaki H
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Journal Title
Prenat Diagn
Volume: 34
Pages: 345-349
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[Journal Article] Characterization of placenta-specific microRNAs in fetal growth restriction pregnancy2013
Author(s)
Higashijima A, Miura K, Mishima H, Kinoshita A, Jo O, Abe S, Hasegawa Y, Miura S, Yamasaki K, Yoshida A, Yoshiura KI, and Masuzaki H
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Journal Title
Prenatal Diagnosis
Volume: 33
Pages: 214-222
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[Journal Article] Copy number variation of the antimicrobial-gene, defensin beta 4, is associated with susceptibility to cervical cancer2013
Author(s)
Abe S, Miura K, Kinoshita A, Mishima H, Miura S, Yamasaki K, Hasegawa Y, Higashijima A, Jo O, Sasaki K, Yoshida A, Yoshiura KI, and Masuzaki H
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Journal Title
J Hum Genet
Volume: 58
Pages: 250-253
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[Journal Article] IFPA Meeting 2012 Workshop Report III : Trophoblast deportation, gestational trophoblastic disease, placental insufficiency and fetal growth restriction, trophoblast over-invasion and accreta-related pathologies, placental thrombosis and fibrinolysis2013
Author(s)
Al-Khan A, Bulmer JN, Chantraine F, Chen CP, Chen Q, Collins S, Cotechini T, Fitzgerald JS, He M, Holland O, Hung TH, Illsley NP, Ino K, Iwaki T, Kanayama N, Kaneki E, Katabuchi H, Kobayashi Y, Kondo A, Masuzaki H, Matjila M, Miura K, Mori A, Murthi P, Nagahashi K, Nie G, Ohba T, Sood R, Sugimura M, Takizawa T, Usui H, Velicky P, Lash GE.
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Journal Title
Placenta
Volume: S0143-4004 (12)
Pages: 453-455
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[Journal Article] Clinical application of fetal sex determination using cell-free fetal DNA in pregnant carriers of X-linked genetic disorders2011
Author(s)
Miura K, Higashijima A, Shimada T, Miura S, Yamasaki K, Abe S, Jo O, Kinoshita A, Yoshida A, Yoshimura S, Niikawa N, Yoshiura K, and Masuzaki H
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Journal Title
Journal of Human Genetics
Volume: 56
Pages: 296-299
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[Journal Article] Epidemiology of human papillomavirus genotypes in pregnant Japanese women2011
Author(s)
Yamasaki K, Miura K, Shimada T, Miura S, Abe S, Murakami M, Sameshima T, Fujishita A, Kotera K, Kinoshita A, Yoshiura K, and Masuzaki H
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Journal Title
Journal of Human Genetics
Volume: 56
Pages: 313-315
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[Journal Article] Pre-vaccination epidemiology of human papillomavirus infections in Japanese women with abnormal cytology2011
Author(s)
Yamasaki K, Miura K, Shimada T, Ikemoto R, Miura S, Murakami M, Sameshima T, Fujishita A, Kotera K, Kinoshita A, Yoshiura K, Masuzaki H
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Journal Title
Journal of Obstetrics and Gynaecology Research
Volume: 37
Pages: 1666-1670
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[Journal Article] Guidelines for obstetrical practice in Japan : Japan Society of Obstetrics and Gynecology (JSOG) and Japan Association of Obstetricians and Gynecologists (JAOG) 2014 edition
Author(s)
Minakami H, Maeda T, Fujii T, Hamada H, Iitsuka Y, Itakura A, Itoh H, Iwashita T, Kanagawa T, Kanai M, Kasuga Y, Kawabata M, Kobayashi K, Kotani T, Kudo Y, Makino Y, Matsubara S, Matsuda H, Miura K, Murakoshi T, Murotsuki J, Ohkuchi A, Ohno Y, Ohshiba Y, Satoh S, Sekizawa A, Sugiura M, Suzuki S, Takahashi T, Tsukahara Y, Unno N, Yoshikawa H
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Journal Title
Journal of Obstetrics and Gynaecology Research
Volume: (in press)
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[Journal Article] Single human papillomavirus 16 or 52 infection and later cytological findings in Japanese women with NILM or ASC-US
Author(s)
Abe S, Miura K, Kinoshita A, Mishima H, Miura S, Yamasaki K, Hasegawa Y, Higashijima A, Jo O, Yoshida A, Kaneuchi M, Yoshiura KI and Masuzaki H
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Journal Title
Journal of Human Genetics
Volume: (in press)
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