2013 Fiscal Year Final Research Report
Development of new therapeutic strategy and clinical application for implantation failure
| Project/Area Number |
23592412
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Saitama Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
ITAKURA Atsuo 順天堂大学, 医学部, 教授 (70262897)
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| Co-Investigator(Renkei-kenkyūsha) |
ISHIHARA Osamu 埼玉医科大学, 医学部, 教授 (70176212)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 生殖医学 / 着床 / 不妊症 |
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| Research Abstract |
A recent clinical trial demonstrated a beneficial effect of heparin administration in the luteal phase on implantation rate as well as the live birth rate in women with repeated implantation failure. However, the precise effects of heparin on decidualization process remain uncertain. Addition of heparin at various concentrations to decidualized HESCs caused a dose-dependent increase of PRL secretion. Decidualized HESCs treated with heparin dose-dependently prevented the cell death rate induced by oxidative stress. Heparin augmented both FOXO1 and SOD2 protein expression. These results demonstrate that heparin-treated decidualized HESCs acquired resistance to oxidative stress by induced expression of FOXO1 and SOD2, suggesting that heparin may improve the uterine environment for successful implantation.
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[Journal Article] Androgens modulate the morphological characteristics of human endometrial stromal cells decidualized in vitro2014
Author(s)
Kajihara T, Tanaka K, Oguro T, Tochigi H, Prechapanich J, Uchino S, Itakura A, Sućurović S, Murakami K, Brosens JJ, Ishihara O
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Journal Title
Reprod Sci
Volume: 21(3)
Pages: 372-80
DOI
Peer Reviewed
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[Journal Article] Effect of a dienogest for anexperimental three-dimensional endometrial culture model for endometriosis2013
Author(s)
Prechapanich J, Kajihara T, Fujita K, Sato K, Uchino S, Tanaka K, Matsumoto S,Akita M, Nagashima M, Brosens JJ, Ishihara O
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Journal Title
Med Mol Morphol
Volume: (Epub ahead of print)
Peer Reviewed
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