Study of the relationship between the expression of microRNAs and gynecologic malignancies

2014 Fiscal Year Final Research Report

• Project/Area Number: 23592428
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Obstetrics and gynecology
• Research Institution: Nagasaki University (2013-2014); Hokkaido University (2011-2012)
• Principal Investigator: KANEUCHI Masanori 長崎大学, 病院(医学系), 講師 (60333613)
• Co-Investigator(Kenkyū-buntansha): SAKURAGI Noriaki 北海道大学, 医学(系)研究科(研究院), 特任教授 (70153963)
• Research Collaborator: DONG Peixin
• Project Period (FY): 2011-04-28 – 2015-03-31
• Keywords: 卵巣癌 / 絨毛癌 / 子宮内膜癌 / マイクロＲＮＡ

Outline of Final Research Achievements

We found that the microRNA-30c, 99a, 130a, 141 were differently expressed among ovarian cancer cell lines. The different expression of these micro RNAs may characterize different histological type of ovarian cancer. And, the expression of microRNA-141,200a, 200c, 345 were up-regulated in ovarian clear cell carcinoma. These micro-RNAs might be responsible for ovarian carcinogenesis. Compared to the cell line derived from normal villi, expression of microRNA-512, 517, 518, 519, 526 were up-regulated, and that of microRNA-125b was markedly down-regulated in choriocarcinoma cell lines. These micro-RNAs might be responsible for occurrence of choriocarcinoma. We also found that the expression of microRNA-106b and Kruppel-like factor 17(KLF17) correlated with the different malignant potential of endometrial cancer.
Further investigation to evaluate the expressions of microRNAs may contribute to the earlier diagnosis or treatment of gynecologic cancers.

Free Research Field

外科系臨床医学産婦人科学