2013 Fiscal Year Final Research Report
Development of molecular targeted therapeutics and its biomarkers in endometrial and ovarian clear cell carcinomas
| Project/Area Number |
23592437
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
ODA Katsutoshi 東京大学, 医学部附属病院, 准教授 (30359608)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 子宮体癌 / 卵巣癌 / 分子標的治療 / ゲノム解析 / バイオマーカー / PI3K / cyclin D1 / DNA修復 |
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| Research Abstract |
We elucidated a novel molecular targeted therapeutics and its predictive biomarkers in endometrial and ovarian clear cell adenocarcinomas, on basis of the aberrant signaling pathways in these cancers.
1. We found that a PI3K pathway inhibitor (dual PI3K/mTOR inhibitor) is effective in endometrial and ovarian clear cell adenocarcinomas. Furthermore, mutational status of KRAS and TP53 was indicated as predictive biomarkers to the PI3K/mTOR inhibitor.
2. We revealed that genome-wide analyses, including single nucleotide polymorphism arrays, are useful for both diagnosis and prediction of prognosis in synchronous endometrial and ovarian carcinomas. In addition, we reported that activation of cyclin D1 and disruption of DNA repair pathways play important roles in endometrial cancer.
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Author(s)
Inaba K, Nagasaka K, Kawana K, Arimoto T, Matsumoto Y, Tsuruga T, Mori Uchino M, Miura S, Sone K, Oda K, et al
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Journal Title
J Obstet Gynaecol Res
Volume: 40
Pages: 554-560
DOI
Peer Reviewed
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[Journal Article] Matrix Metalloproteinase (MMP)-9 in Cancer-Associated Fibroblasts (CAFs) Is Suppressed by Omega-3 Polyunsaturated Fatty Acids In Vitro and In Vivo2014
Author(s)
Taguchi A, Kawana K, Tomio K, Yamashita A, Isobe Y, Nagasaka K, Koga K, Inoue T, Nishida H, Kojima S, Adachi K, Matsumoto Y, Arimoto T, Wada-Hiraike O, Oda K, et al
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Journal Title
PLoS One
Volume: 9
Pages: e89605
DOI
Peer Reviewed
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[Journal Article] Omega-3 polyunsaturated Fatty acids suppress the cystic lesion formation of peritoneal endometriosis in transgenic mouse models2013
Author(s)
Tomio K, Kawana K, Taguchi A, Isobe Y, Iwamoto R, Yamashita A, Kojima S, Mori M, Nagamatsu T, Arimoto T, Oda K, et al
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Journal Title
PLoS One
Volume: 8
Pages: e73085
DOI
Peer Reviewed
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[Journal Article] The prevalence of cervical regulatory T cells in HPV-related cervical intraepithelial neoplasia correlates inversely with spontaneous regression of CIN2013
Author(s)
Kojima S, Kawana K, Tomio K, Yamashita A, Taguchi A, Miura S, Adachi K, Nagamatsu T, Nagasaka K, Matsumoto Y, Arimoto T, Oda K, et al
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Journal Title
Am J Reprod Immunol
Volume: 69
Pages: 134-141
DOI
Peer Reviewed
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[Journal Article] Increased tissue levels of omega-3 polyunsaturated fatty acids prevents pathological preterm birth2013
Author(s)
Yamashita A, Kawana K, Tomio K, Taguchi A, Isobe Y, Iwamoto R, Masuda K, Furuya H, Nagamatsu T, Nagasaka K, Arimoto T, Oda K, et al
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Journal Title
Sci Rep
Volume: 3
Pages: 3113
DOI
Peer Reviewed
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[Journal Article] Role of multifunctional transcription factor TFII-I and putative tumour suppressor DBC1 in cell cycle and DNA double strand damage repair2013
Author(s)
Tanikawa M, Wada-Hiraike O, Yoshizawa- Sugata N, Shirane A, Hirano M, Hiraike H, Miyamoto Y, Sone K, Ikeda Y, Kashiyama T, Oda K, et al
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Journal Title
Br J Cancer
Volume: 109
Pages: 3042-3048
DOI
Peer Reviewed
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[Journal Article] Resveratrol promotes expression of SIRT1 and StAR in rat ovarian granulosa cells : an implicative role of SIRT1 in the ovary2012
Author(s)
Morita Y, Wada Hiraike O, Yano T, Shirane A, Hirano M, Hiraike H, Koyama S, Oishi H, Yoshino O, Miyamoto Y, Sone K, Oda K, et al
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Journal Title
Reprod Biol Endocrinol
Volume: 10
Pages: 14
DOI
Peer Reviewed
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[Journal Article] Multifunctional transcription factor TFII-I is an activator of BRCA1 function2011
Author(s)
Tanikawa M, Wada Hiraike O, Nakagawa S, Shirane A, Hiraike H, Koyama S, Miyamoto Y, Sone K, Tsuruga T, Nagasaka K, Matsumoto Y, Ikeda Y, Shoji K, Oda K, et al
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Journal Title
Br J Cancer
Volume: 104
Pages: 1349-1355
DOI
Peer Reviewed
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