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2013 Fiscal Year Final Research Report

Hypoxic cytotoxin TX-402 might inhibit the expansion of cancer stem cells in ovarian cancer.

Research Project

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Project/Area Number 23592443
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Obstetrics and gynecology
Research InstitutionGifu University

Principal Investigator

MORISHIGE Ken-ichirou  岐阜大学, 医学(系)研究科(研究院), 教授 (90283788)

Co-Investigator(Kenkyū-buntansha) ITO Naoki  岐阜大学, 医学部附属病院, 講師 (30184675)
FURUI Tatsurou  岐阜大学, 大学院医学系研究科, 准教授 (00313883)
TOYOKI Hiroshi  岐阜大学, 医学部附属病院, 講師 (40402169)
HAYASAKI You  岐阜大学, 大学院医学系研究科, 助教 (20566492)
Project Period (FY) 2011 – 2013
Keywords卵巣癌 / 癌幹細胞 / 低酸素 / HIF / がん幹細胞
Research Abstract

In the solid tumor, the region away from the vasculatures are hypoxic and recent studies have revealed that hypoxia inducible factor (HIF) increases the fraction of cancer stem cells (CSCs). TX-402, developed as a hypoxic cytotoxin, inhibited the expression of HIF.We supposed that TX-402 might be a possible candidate as a molecular-targeted drug for ovarian cancer by inhibiting CSC expansion. Hypoxia induced the expression of HIF, stem cell factors, and putative CSC markers. Furthermore, TX-402 inhibited these stem cell factors and CSC markers, dose-dependently.
Next, we constructed the spheroids of ovarian cancer cell line, as a 3D hypoxia model, in which the internal hypoxic region contained CSCs. These hypoxic regions containing CSCs was disappeared by the treatment with TX-402.In conclusion, hypoxia might promote the expansion of CSCs, and TX-402 could be useful for ovarian cancer by inhibiting the hypoxia-induced CSC expansion.

  • Research Products

    (14 results)

All 2013 2012 2011

All Journal Article (9 results) (of which Peer Reviewed: 9 results) Presentation (5 results)

  • [Journal Article] An Impact of the Specialization in gynecology and obstetrics departments on pregnant women's choice for maternity institutions2013

    • Author(s)
      Adachi Y, Iso H, Shen J, Ban K, Fukui O, Hashimoto H, Nakashima T, Morishige K, Saijo T
    • Journal Title

      Health Economics Review

      Volume: 3(1) Pages: 31

    • DOI

      10.1186/2191-1991-3-31

    • Peer Reviewed
  • [Journal Article] Ovarian fibromas : MR imaging findings with emphasis on intratumoral cyst formation2013

    • Author(s)
      Kato H, Kanematsu M, Ono H, Yano R, Furui T, Morishige KI, Hatano Y
    • Journal Title

      Eur J Radiol

      Volume: 82(9) Pages: e417-e421

    • DOI

      10.1016/j.ejrad.2013.04.010

    • Peer Reviewed
  • [Journal Article] miR-92a Inhibits Peritoneal Dissemination of Ovarian Cancer Cells by Inhibiting Integrinα5 Expression2013

    • Author(s)
      Ohyagi-Hara C,Sawada K, Kamiura S, Tomita Y, Isobe A, Hashimoto K, Kinose Y, Mabuchi S, Hisamatsu T, Takahashi T, Kumasawa K, Nagata S, Morishige KI, Lengyel E, Kurachi H,Kimura T
    • Journal Title

      Am J Pathol

      Volume: 182 (5) Pages: 1876-1889

    • DOI

      10.1016/j.ajpath.2013.01.039

    • Peer Reviewed
  • [Journal Article] Ovarian mucinous cystadenoma coexisting with benign Brenner tumor : MR imaging findings2012

    • Author(s)
      Kato H, Kanematsu M, Furui T, Morishige KI, Hirose Y
    • Journal Title

      Abdom Imaging

      Volume: 38(2) Pages: 412-416

    • DOI

      10.1007/s00261-012-9887-1

    • Peer Reviewed
  • [Journal Article] A cost-benefit analysis on the specialization in departments of obstetrics and gynecology in Japan2012

    • Author(s)
      Shen J, Fukui O, Hashimoto H, Nakashima T, Kimura T, Morishige K, Saijo T
    • Journal Title

      Health Economics Review

      Volume: 2(1) Pages: 2

    • DOI

      10.1186/2191-1991-2-2.

    • Peer Reviewed
  • [Journal Article] Integrin Inhibitors as a Therapeutic Agent for Ovarian Cancer2012

    • Author(s)
      Sawada K, Ohyagi-Hara C, Kimura T Morishige K-I
    • Journal Title

      J Oncol

    • DOI

      10.1155/2012/915140.

    • Peer Reviewed
  • [Journal Article] Postpartum hemorrhage in coagulopathic patients : preliminary experience with uterine arterial embolization with N-butyl cyanoacrylate2011

    • Author(s)
      Kanematsu M, Watanabe H, Kondo H, Goshima S, Kato H, Furui T, Toyoki H, Morishige K
    • Journal Title

      J Vasc Interv Radiol

      Volume: 22(12) Pages: 1773-1776

    • DOI

      10.1016/j.jvir.2011.08.016

    • Peer Reviewed
  • [Journal Article] Chemotherapy for endometrial carcinoma (GOGO-EM1 study): TEC (paclitaxel, epirubicin, and carboplatin) is an effective remission-induction and adjuvant therapy2011

    • Author(s)
      Egawa-Takata T, Ueda Y, Kuragaki C, Miyake T, Miyatake T, Fujita M, Yoshino K, Nakashima R, Okazawa M, Tsutsui T, Morishige KI, Kimura T, Yamasaki M, Nishizaki T, Nagamatsu M, Ito K, Asada M, Ogita K, Wakimoto A, Yamamoto T, Nishio Y, Enomoto T
    • Journal Title

      Cancer Chemother Pharmacol

      Volume: 68(6) Pages: 1603-1610

    • DOI

      10.1007/s00280-011-1638-4.

    • Peer Reviewed
  • [Journal Article] Postoperative whole pelvic radiotherapy plus concurrent chemotherapy versus extended-field irradiation for early-stage cervical cancer patients with multiple pelvic lymph node metastases2011

    • Author(s)
      Mabuchi S, Okazawa M, Isohashi F, Ohta Y, Maruoka S, Yoshioka Y, Enomoto T, Morishige K, Kamiura S, Kimura T
    • Journal Title

      Gynecol Oncol

      Volume: 120(1) Pages: 94-100

    • DOI

      10.1016/j.ygyno.2010.09.016.

    • Peer Reviewed
  • [Presentation] Relationship between therapy for uterine cervical cancer and body composition on premenopausal women2013

    • Author(s)
      Kawashima E, Sugiyama M, Misao A, Fujimoto J, Morishige K-I
    • Organizer
      The 5th Scientific Meeting of the Asia Pacific Menopause Federation
    • Place of Presentation
      Japan, Tokyo
    • Year and Date
      20131018-20
  • [Presentation] 卵巣明細胞がんにおける癌幹細胞マーカーALDH1の関与2012

    • Author(s)
      水野智子、牧野弘、鈴木紀子、小倉寛則、森重健一郎
    • Organizer
      第50回日本癌治療学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      20121025-27
  • [Presentation] 卵巣癌におけるHIF-1阻害剤によるcancer stem cell-like cellの増大抑制効果に関する検討2012

    • Author(s)
      鈴木紀子、小倉寛則、永澤秀子、森重健一郎
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      札幌
    • Year and Date
      20120919-21
  • [Presentation] 当科における上皮性卵巣癌の再発後長期生存例の検討2012

    • Author(s)
      牧野弘、小倉寛則、森重健一郎
    • Organizer
      第52回日本婦人科腫瘍学会学術講演会
    • Place of Presentation
      東京
    • Year and Date
      20120719-21
  • [Presentation] Lengyel E, Kimura T : Identification of microRNA which regulates peritoneal dissemination of ovarian cancer2011

    • Author(s)
      Ohyagi C, Sawada K, Morishige K-I
    • Organizer
      American Association for Cancer Research 102nd Annual Meeting 2011
    • Place of Presentation
      Orlando, USA
    • Year and Date
      20110402-06

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Published: 2015-07-16  

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