2013 Fiscal Year Final Research Report
Identification of "oncogenic kinase" in ovarian cancer
| Project/Area Number |
23592449
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Obstetrics and gynecology
|
|---|
| Research Institution | Kobe University |
|---|
Principal Investigator |
SUDO Tamotsu 神戸大学, 医学(系)研究科(研究院), 医学研究員 (50397824)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
IGUCHI Taisen 大学共同利用機関法人自然科学研究機構(共通施設), 岡崎統合バイオサイエンスセンター, 教授 (90128588)
|
|---|
| Project Period (FY) |
2011 – 2013
|
| Keywords | 卵巣癌 / リン酸化酵素 |
|---|
| Research Abstract |
We clarified that PTK6, protein-tyrosine kinase-6, is over-expressed in ovarian cancers through demethylation of PTK6 gene. Ovarian cancer patients with over expression of PTK6 tend to have poor prognoses.
We developed a novel 3D cell culture system named Cell-able.The spheroids derived from ovarian cancer tissues could be grown on Cell-able.The incorporation of EdU and staining with Caspase 3/7 were useful for evaluating the sensitivity for chemotherapeutic agents and molecular targeting agents.
|
Research Products
(34 results)
-
-
-
[Journal Article] Boron neutron capture therapy as new treatment for clear cell sarcoma: Trial on different animal model2014
Author(s)
Andoh T, Fujimoto T, Sudo T, Suzuki M, Sakurai Y, Sakuma T, Moritake H, Sugimoto T, Takeuchi T, Sonobe H, Epstein AL, Fukumori Y, Ono K, Ichikawa H
-
Journal Title
Appl Radiat Isot
Volume: 88
Pages: 59-63
Peer Reviewed
-
-
-
-
[Journal Article] Boron neutron capture therapy (BNCT) selectively destroys human clear cell sarcoma in mouse model2013
Author(s)
Fujimoto T, Andoh T,Sudo T, Fujita I, Moritake H, Sugimoto T, Sakuma T, Akisue T, Kawabata S, Kirihata M, Suzuki M, Sakurai Y, Ono K, Fukumori Y, Kurosaka M, Ichikawa H
-
Journal Title
Appl Radiat Isot
Volume: 73
Pages: 96-100
Peer Reviewed
-
[Journal Article] Endometrial stromal sarcoma: clinicopathological and immunophenotypic study of 16 cases2013
Author(s)
Shin-ichi Iwasaki, Tamotsu Sudo, Maiko Miwa,Masayo Ukita, Akemi Morimoto, Masaru Tamada, Sayaka Ueno, Senn Wakahash, Satoshi Yamaguchi, Kiyoshi Fujiwara, Yoshiko Sakuma, Yoshiki Mikami, Ryuichiro Nishimura
-
Journal Title
Arch Gynecol Obstet
Volume: 288(2)
Pages: 385-91
Peer Reviewed
-
-
-
[Journal Article] Potential role of LMP2 as an anti-oncogenic factor in human uterine leiomyosarcoma: morphological significance of calponin h12012
Author(s)
Hayashi T, Horiuchi A, Sano K, Hiraoka N, Kasai M, Ichimura T, Sudo T, Nishimura R, Ishiko O, Shiozawa T, Kanai Y, Yaegashi N, Aburatani H, Konishi I
-
Journal Title
FEBS Lett
Volume: 586(13)
Pages: 1824-31
Peer Reviewed
-
[Journal Article] High-risk ovarian cancer based on 126-gene expression signature is uniquely characterized by down regulation of antigen presentation pathway2012
Author(s)
Yoshihara K, Tsunoda T, Shigemizu D, Fujiwara H, Hatae M, Fujiwara H, Masuzaki H, Katabuchi H, Kawakami Y, Okamoto A, Nogawa T, Matsumura N, Udagawa Y, Saito T, Itamochi H, Takano M, Miyagi E, Sudo T, Ushijima K, Iwase H, Seki H, Terao Y, Enomoto T, Mikami M, Akazawa K, Tsuda H, Moriya T, Tajima A, Inoue I, Tanaka K
-
Journal Title
Clin Cancer Res
Volume: 18(5)
Pages: 1374-85
Peer Reviewed
-
-
-
-
-
[Journal Article] Boron neutron capture therapy for clear cell sarcoma (CCS): Biodistribution study of p-borono-l-phenylalanine in CCS-bearing animal models2011
Author(s)
Andoh T, Fujimoto T, Sudo T, Fujita I, Imabori M, Moritake H, Sugimoto T, Sakuma Y, Takeuchi T, Kawabata S, Kirihata M, Akisue T, Yayama K, Kurosaka M, Miyatake S, Fukumori Y, Ichikawa H
-
Journal Title
Appl Radiat Isot
Volume: 69(12)
Pages: 1721-4
Peer Reviewed
-
[Journal Article] Evaluation of BPA uptake in clear cell sarcoma (CCS) in vitro and development of an in vivo model of CCS for BNCT studies2011
Author(s)
Fujimoto T, Andoh T, Sudo T, Fujita I, Imbabura M, Moritake H, Sugimoto T, Sakuma Y, Takeuchi T, Sonobe H, Epstein AL, Akisue T, Kirihata M, Kurosaka M, Fukumori Y, Ichikawa H
-
Journal Title
2011 Appl Radiat Isot
Volume: 69(12)
Pages: 1713-6
Peer Reviewed
-
-
-
-
-
[Presentation] Activation of EGFR-PI3K-Akt pathway in cervical clear cell carcinoma2012
Author(s)
Ueno S, Sudo T, Miwa M, Morimoto A, Ukita M, Iwasaki S, Wakahashi S, Yamaguchi S, Fujiwara K ,Nishimura N and Mikami Y
Organizer
14th Biennial Meeting of the International Gynecologic Cancer Society (IGCS)
Place of Presentation
Vancouver, Canada
Year and Date
2012-10-13
-
-
-
-
-
-
-
-
-
-
-
