• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2013 Fiscal Year Final Research Report

Identification of "oncogenic kinase" in ovarian cancer

Research Project

  • PDF
Project/Area Number 23592449
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Obstetrics and gynecology
Research InstitutionKobe University

Principal Investigator

SUDO Tamotsu  神戸大学, 医学(系)研究科(研究院), 医学研究員 (50397824)

Co-Investigator(Kenkyū-buntansha) IGUCHI Taisen  大学共同利用機関法人自然科学研究機構(共通施設), 岡崎統合バイオサイエンスセンター, 教授 (90128588)
Project Period (FY) 2011 – 2013
Keywords卵巣癌 / リン酸化酵素
Research Abstract

We clarified that PTK6, protein-tyrosine kinase-6, is over-expressed in ovarian cancers through demethylation of PTK6 gene. Ovarian cancer patients with over expression of PTK6 tend to have poor prognoses.
We developed a novel 3D cell culture system named Cell-able.The spheroids derived from ovarian cancer tissues could be grown on Cell-able.The incorporation of EdU and staining with Caspase 3/7 were useful for evaluating the sensitivity for chemotherapeutic agents and molecular targeting agents.

  • Research Products

    (34 results)

All 2014 2013 2012 2011 2010

All Journal Article (22 results) (of which Peer Reviewed: 22 results) Presentation (11 results) Book (1 results)

  • [Journal Article] Unique roles of estrogen-dependent Pten control in epithelial cell homeostasis of mouse vagina2014

    • Author(s)
      Miyagawa S, Sato M, Sudo T, Yamada G, Iguchi T
    • Journal Title

      Oncogene

    • Peer Reviewed
  • [Journal Article] Alpha-fetoprotein-producing ovarian clear cell adenocarcinoma simulating fetal gut in a postmenopausal woman2014

    • Author(s)
      Akemi Morimoto, Tamotsu Sudo, Toshiko Sakuma, Masanori Yasuda, Kiyoshi Fujiwara
    • Journal Title

      Gynecologic Oncology Reports

      Volume: 8 Pages: 24-26

    • Peer Reviewed
  • [Journal Article] Boron neutron capture therapy as new treatment for clear cell sarcoma: Trial on different animal model2014

    • Author(s)
      Andoh T, Fujimoto T, Sudo T, Suzuki M, Sakurai Y, Sakuma T, Moritake H, Sugimoto T, Takeuchi T, Sonobe H, Epstein AL, Fukumori Y, Ono K, Ichikawa H
    • Journal Title

      Appl Radiat Isot

      Volume: 88 Pages: 59-63

    • Peer Reviewed
  • [Journal Article] Histopathology predicts clinical outcome in advanced epithelial ovarian cancer patients treated with neoadjuvant chemotherapy and debulking surgery2013

    • Author(s)
      Muraji M, Sudo T, Iwasaki S, Ueno S, Wakahashi S, Yamaguchi S, Fujiwara K, Nishimura R
    • Journal Title

      Gynecol Oncol

      Volume: 131(3) Pages: 531-4

    • Peer Reviewed
  • [Journal Article] VAV1 represses E-cadherin expression through the transactivation of Snail and Slug: a potential mechanism for aberrant epithelial to mesenchymal transition in human epithelial ovarian cancer2013

    • Author(s)
      Wakahashi S, Sudo T, Oka N, Ueno S, Yamaguchi S, Fujiwara K, Ohbayashi C, Nishimura R
    • Journal Title

      Transl Res

      Volume: 162(3) Pages: 181-90

    • Peer Reviewed
  • [Journal Article] Absence of human papillomavirus infection and activation of PI3K-AKT pathway in cervical clear cell carcinoma2013

    • Author(s)
      Ueno S, Sudo T, Oka N, Wakahashi S, Yamaguchi S, Fujiwara K, Mikami Y, Nishimura R
    • Journal Title

      Int J Gynecol Cancer

      Volume: 23(6) Pages: 1084-91

    • Peer Reviewed
  • [Journal Article] Boron neutron capture therapy (BNCT) selectively destroys human clear cell sarcoma in mouse model2013

    • Author(s)
      Fujimoto T, Andoh T,Sudo T, Fujita I, Moritake H, Sugimoto T, Sakuma T, Akisue T, Kawabata S, Kirihata M, Suzuki M, Sakurai Y, Ono K, Fukumori Y, Kurosaka M, Ichikawa H
    • Journal Title

      Appl Radiat Isot

      Volume: 73 Pages: 96-100

    • Peer Reviewed
  • [Journal Article] Endometrial stromal sarcoma: clinicopathological and immunophenotypic study of 16 cases2013

    • Author(s)
      Shin-ichi Iwasaki, Tamotsu Sudo, Maiko Miwa,Masayo Ukita, Akemi Morimoto, Masaru Tamada, Sayaka Ueno, Senn Wakahash, Satoshi Yamaguchi, Kiyoshi Fujiwara, Yoshiko Sakuma, Yoshiki Mikami, Ryuichiro Nishimura
    • Journal Title

      Arch Gynecol Obstet

      Volume: 288(2) Pages: 385-91

    • Peer Reviewed
  • [Journal Article] L1 gene methylation in high-risk human papillomaviruses for the prognosis of cervical intraepithelial neoplasia2013

    • Author(s)
      Oka N, Kajita M, Nishimura R, Ohbayashi C and Sudo T
    • Journal Title

      Int J Gynecol Cancer

      Volume: 23(2) Pages: 235-43

    • Peer Reviewed
  • [Journal Article] Molecular-targeted therapies for ovarian cancer: prospects for the future2012

    • Author(s)
      Sudo T
    • Journal Title

      Int J Clin Oncol

      Volume: 17(5) Pages: 424-9

    • Peer Reviewed
  • [Journal Article] Potential role of LMP2 as an anti-oncogenic factor in human uterine leiomyosarcoma: morphological significance of calponin h12012

    • Author(s)
      Hayashi T, Horiuchi A, Sano K, Hiraoka N, Kasai M, Ichimura T, Sudo T, Nishimura R, Ishiko O, Shiozawa T, Kanai Y, Yaegashi N, Aburatani H, Konishi I
    • Journal Title

      FEBS Lett

      Volume: 586(13) Pages: 1824-31

    • Peer Reviewed
  • [Journal Article] High-risk ovarian cancer based on 126-gene expression signature is uniquely characterized by down regulation of antigen presentation pathway2012

    • Author(s)
      Yoshihara K, Tsunoda T, Shigemizu D, Fujiwara H, Hatae M, Fujiwara H, Masuzaki H, Katabuchi H, Kawakami Y, Okamoto A, Nogawa T, Matsumura N, Udagawa Y, Saito T, Itamochi H, Takano M, Miyagi E, Sudo T, Ushijima K, Iwase H, Seki H, Terao Y, Enomoto T, Mikami M, Akazawa K, Tsuda H, Moriya T, Tajima A, Inoue I, Tanaka K
    • Journal Title

      Clin Cancer Res

      Volume: 18(5) Pages: 1374-85

    • Peer Reviewed
  • [Journal Article] The effect of abdominal radical trachelectomy on ovarian reserve: serial changes in serum anti-mullerian hormone levels2012

    • Author(s)
      Muraji M, Sudo T, Iwasaki S, Ueno S, Wakahashi S, Yamaguchi S, Fujiwara K, Nishimura R
    • Journal Title

      Journal of Cancer

      Volume: 3 Pages: 191-5

    • Peer Reviewed
  • [Journal Article] Endometrioid adenocarcinoma with high-grade transformation with serous and choriocarcinomatous differentiation - a case report2012

    • Author(s)
      Senn Wakahashi, Tamotsu Sudo, Chiho Ohbayashi
    • Journal Title

      Journal of Cancer

      Volume: 3 Pages: 14-8

    • Peer Reviewed
  • [Journal Article] Type II versus Type III fertility-sparing abdominal radical trachelectomy for early stage cervical cancer: a comparison of feasibility of surgical outcomes2012

    • Author(s)
      Miho MURAJI, Tamotsu SUDO, Ryuichiro NISHIMURA
    • Journal Title

      Int J Gynecol Cancer

      Volume: 22(3) Pages: 479-83

    • Peer Reviewed
  • [Journal Article] Potential role of LMP2 as tumor-suppressor defines new targets for uterine leiomyosarcoma therapy2011

    • Author(s)
      Takuma Hayashi, Akiko Horiuchi, Kenji Sano, Nobuyoshi Hiraoka, Mari Kasai, Tomoyuki Ichimura, Tamotsu Sudo, Nobuo Yaegashi , Hiroyuki Aburatani, Tanri Shiozawa
    • Journal Title

      Ikuo Konishi Scientific Reports

      Volume: 1 Pages: 180

    • Peer Reviewed
  • [Journal Article] Boron neutron capture therapy for clear cell sarcoma (CCS): Biodistribution study of p-borono-l-phenylalanine in CCS-bearing animal models2011

    • Author(s)
      Andoh T, Fujimoto T, Sudo T, Fujita I, Imabori M, Moritake H, Sugimoto T, Sakuma Y, Takeuchi T, Kawabata S, Kirihata M, Akisue T, Yayama K, Kurosaka M, Miyatake S, Fukumori Y, Ichikawa H
    • Journal Title

      Appl Radiat Isot

      Volume: 69(12) Pages: 1721-4

    • Peer Reviewed
  • [Journal Article] Evaluation of BPA uptake in clear cell sarcoma (CCS) in vitro and development of an in vivo model of CCS for BNCT studies2011

    • Author(s)
      Fujimoto T, Andoh T, Sudo T, Fujita I, Imbabura M, Moritake H, Sugimoto T, Sakuma Y, Takeuchi T, Sonobe H, Epstein AL, Akisue T, Kirihata M, Kurosaka M, Fukumori Y, Ichikawa H
    • Journal Title

      2011 Appl Radiat Isot

      Volume: 69(12) Pages: 1713-6

    • Peer Reviewed
  • [Journal Article] The direct PAK1 inhibitor, TAT-PAK18, blocks preferentially the growth of human ovarian cancer cell lines in which PAK1 is abnormally activated by autophosphorylation at Thr 4232010

    • Author(s)
      Hashimoto H, Sudo T, Maruta H, Nishimura R.
    • Journal Title

      Drug Discov Ther

      Volume: 4(1) Pages: 1-4

    • Peer Reviewed
  • [Journal Article] Absence of high-risk human papillomavirus (HPV) detection in endocervical adenocarcinoma with gastric morphology and phenotype2010

    • Author(s)
      Kusanagi Y, Kojima A, Mikami Y, Kiyokawa T, Sudo T, Yamaguchi S, Nishimura R
    • Journal Title

      Am J Pathol

      Volume: 177(5) Pages: 2169-75

    • Peer Reviewed
  • [Journal Article] Relationship between ABCF2 expression and response to chemotherapy or prognosis in clear cell adenocarcinoma of the ovary2010

    • Author(s)
      Tsuda H, Ito K, Yaegashi N, Hirasawa A, Sudo T, Kita T, Terai Y, Kigawa J, Sugiyama T, Aoki D
    • Journal Title

      Int J Gynecol Cancer

      Volume: 20(5) Pages: 794-7

    • Peer Reviewed
  • [Journal Article] Estrogen Receptor ESR1 Is Indispensable for the Induction of Persistent Vaginal Change by Neonatal 5alpha-Dihydrotestosterone Exposure in Mice2010

    • Author(s)
      Shinichi Miyagawa, Yoshinao Katsu, Yasuhiko Ohta, Tamotsu Sudo, Dennis B. Lubahn and Taisen Iguchi
    • Journal Title

      Biology of Reproduction

      Volume: 82(3) Pages: 497-503

    • Peer Reviewed
  • [Presentation] Activation of EGFR-PI3K-Akt pathway in cervical clear cell carcinoma2012

    • Author(s)
      Ueno S, Sudo T, Miwa M, Morimoto A, Ukita M, Iwasaki S, Wakahashi S, Yamaguchi S, Fujiwara K ,Nishimura N and Mikami Y
    • Organizer
      14th Biennial Meeting of the International Gynecologic Cancer Society (IGCS)
    • Place of Presentation
      Vancouver, Canada
    • Year and Date
      2012-10-13
  • [Presentation] Vav1はE3 ligase であるHAKAI を介してE-cadherin を抑制し上皮性卵巣癌の上皮間葉移行に関与する2012

    • Author(s)
      若橋宣・植野さやか・連美穂・須藤保
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      北海道
    • Year and Date
      2012-09-20
  • [Presentation] Germ cell differentiation を伴うAFP 産生卵巣癌の一例2012

    • Author(s)
      森本明美・岩﨑真一・植野さやか・若橋宣・須藤保・山口聡・藤原潔・西村隆一郎・佐久間淑子・伊丹弘恵・安田政実
    • Organizer
      第52回日本婦人科腫瘍学会学術講演会
    • Place of Presentation
      東京都
    • Year and Date
      2012-07-21
  • [Presentation] 卵巣癌に対する術前化学療法の組織学的効果判定基準は予後規定因子となりえるか2012

    • Author(s)
      連美穂・森本明美・植野さやか・岩﨑真一・若橋宣・須藤保・山口聡・藤原潔・西村隆一郎
    • Organizer
      第52回日本婦人科腫瘍学会学術講演会
    • Place of Presentation
      東京都
    • Year and Date
      2012-07-20
  • [Presentation] 漿液性腺癌前駆病変の一つとされる卵管上皮内癌(STIC)は浸潤能の高い細胞集団である2012

    • Author(s)
      連美穂・植野さやか・岩﨑真一・若橋宣・山中薫・須藤保・山口聡・藤原潔・西村隆一郎
    • Organizer
      第64回日本産科婦人科学会学術集会
    • Place of Presentation
      神戸
    • Year and Date
      2012-04-13
  • [Presentation] 悪性卵巣腫瘍合併妊娠の全国調査2012

    • Author(s)
      川崎薫・池田智明・西村隆一郎・須藤保
    • Organizer
      第64回日本産科婦人科学会学術集会
    • Place of Presentation
      神戸
    • Year and Date
      2012-04-13
  • [Presentation] Prognostic factors of advanced ovarian cancer patients treated with neoadjuvant chemotherapy2011

    • Author(s)
      Muraji M・Wakahashi S・Sudo T
    • Organizer
      2nd Biennial Meeting og Asian Society of Gynecologic Oncology
    • Place of Presentation
      韓国
    • Year and Date
      2011-11-03
  • [Presentation] VAV1 はE-cadherin を制御することで上皮性卵巣癌の上皮間葉移行に関与する2011

    • Author(s)
      若橋宣・連美穂・須藤保
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-10-03
  • [Presentation] 術前化学療法を施行した上皮性卵巣癌症例での予後規定因子2011

    • Author(s)
      連美穂・若橋宣・須藤保
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-10-03
  • [Presentation] 卵巣癌におけるVAV1-Racl-PAK1 シグナル経路の活性化2011

    • Author(s)
      若橋宣・中村幸司・岩崎真一・植野さやか・連美穂・山中薫・須藤保・山口聡・藤原潔・西村隆一郎
    • Organizer
      第63回日本産科婦人科学会学術講演会
    • Place of Presentation
      大阪
    • Year and Date
      2011-08-30
  • [Presentation] 上皮性卵巣癌再発症例における予後不良因子の検討2011

    • Author(s)
      連美穂・中村幸司・岩崎真一・植野さやか・若橋宣・山中薫・須藤保・山口聡・藤原潔・西村隆一郎
    • Organizer
      第63回日本産科婦人科学会学術講演
    • Place of Presentation
      大阪
    • Year and Date
      2011-08-30
  • [Book] 卵巣癌におけるPTEN/PI3K/AKT/mTOR シグナル 医学のあゆみ Vol.248 No.22014

    • Author(s)
      須藤保
    • Total Pages
      141-145
    • Publisher
      医歯薬出版株式会社

URL: 

Published: 2015-07-16  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi