2013 Fiscal Year Final Research Report
Analysis of carbonyl reductase function -development of the new molecular target therapy-
| Project/Area Number |
23592452
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Yamaguchi University |
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Principal Investigator |
MURAKAMI Akihiro 山口大学, 医学(系)研究科(研究院), 准教授 (70379965)
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| Project Period (FY) |
2011 – 2013
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| Keywords | carbonyl reductase / 上皮間葉転換 / 子宮体癌 |
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| Research Abstract |
Suppression of CBR1 promoted cell proliferation, cell invasion activities, and induced epithelial mesenchymal transition (EMT) in vitro. The tumor volume and weight in CBR1 suppression group were large compared with those in the control group in vivo. The numbers of tumor associated macrophages (TAMs) in stromal tissues was high compared with those in the control group. Therefore, suppression of CBR1 promotes cell invasion activities in vitro by induction of EMT process and cell proliferation activities in vitro and in vivo. Furthermore, suppression of CBR1 may suppress anti-tumor effect and promote pro-tumor effect on TAM. Over-expression of CBR1 has a possibility to be a new molecular target therapy for endometrial cancers.
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