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2013 Fiscal Year Final Research Report

Transplantation of neuronal stem cells prevented ischemia-induced hair cell degeneration by suppressing the production of NOx.

Research Project

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Project/Area Number 23592486
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Otorhinolaryngology
Research InstitutionEhime University

Principal Investigator

HAKUBA NOBUHIRO  愛媛大学, 医学部附属病院, 講師 (70304623)

Project Period (FY) 2011 – 2013
Keywords内耳虚血 / 内有毛細胞 / 神経幹細胞 / 一酸化窒素
Research Abstract

Transplantation of neuronal stem cells (NSCs) is regarded to be a potential approach for promoting repair of damaged organs. Here, we investigated the influence of NSCs on progressive hair cell degeneration after transient cochlear ischemia in gerbils. Transient cochlear ischemia was produced by extracranial occlusion of the bilateral vertebral arteries just before their entry into the transverse foramen of the cervical vertebra. Intrascalar injection of NSC prevented ischemia-induced hair cell degeneration and ameliorated hearing impairment. We also showed that the NOx level in the organ of Corti was suppressed after cochlear ischemia by treatment with NSC. Thus, we propose HSC as a potential new therapeutic strategy for hearing loss by suppressing the production of NOx in the organ of Corti after ischemia.

  • Research Products

    (19 results)

All 2014 2013 2012 2011

All Journal Article (8 results) Presentation (8 results) Book (3 results)

  • [Journal Article] Gelatin hydrogel with basic fibroblast growth factor for tympanic membrane regeneration2014

    • Author(s)
      Hakuba N, Tabata Y, Hato N, Fujiwara T, Gyo K
    • Journal Title

      Otol Neurotol

      Volume: 35(3) Pages: 540-4

  • [Journal Article] Epithelial pearl formation following tympanic membrane regeneration therapy using an atelocollagen/silicone membrane and basic fibroblast growth factor : our experience2013

    • Author(s)
      Hakuba N, Hato N, Omotehara Y, Okada M, Gyo K.
    • Journal Title

      Clin Otolaryng.

    • DOI

      10.1111/coa.12164.

  • [Journal Article] Liposome-encapsulated hemoglobin alleviates hearing loss after transient cochlear ischemia : An experimental study in the gerbil2013

    • Author(s)
      Okada M, Kawaguchi AT, Hakuba N, Hyodo J, Hato N, Gyo K
    • Journal Title

      Neurosci Lett

    • DOI

      10:S0304-3940(13)00776-3.

  • [Journal Article] Treatment of neural anosmia by topical application of basic fibroblast growth factor-gelatin hydrogel in the nasal cavity : an experimental study in mice2013

    • Author(s)
      Nota J, Takahashi H, Hakuba N, Hato N, Gyo K
    • Journal Title

      JAMA Otolaryngol Head Neck Surg

      Volume: 139(4) Pages: 396-400

  • [Journal Article] Myogenin gene expression in the facial muscle following compression or resection of the facial nerve2012

    • Author(s)
      Teraoka M, Hato N, Wakisaka H, Takahashi H, Komobuchi H, Sawai N, Okada M, Hakuba H, Gyo K
    • Journal Title

      Acta Otolaryngol

      Volume: 132(9) Pages: 1013-7

  • [Journal Article] 一過性内耳虚血障害に対するアポトーシス抑制人工ペプチドAM-111の防御効果2011

    • Author(s)
      表原慶典,白馬伸洋,暁清文
    • Journal Title

      頭頸部自律神経

      Volume: 25 Pages: 10-12

  • [Journal Article] Facial nerve decompression surgery in patients with temporal bone trauma : analysis of 66 cases2011

    • Author(s)
      Hato N, Nota J, Hakuba N, Gyo K, Yanagihara N
    • Journal Title

      J Trauma

      Volume: 71(6) Pages: 1789-93

  • [Journal Article] Protection against ischemic cochlear damage by intratympanic administration of AM-1112011

    • Author(s)
      Omotehara Y, Hakuba N, Hato N, Okada M, Gyo K
    • Journal Title

      Otol Neurotol

      Volume: 32(9) Pages: 1422-7

  • [Presentation] The transplantation of stem cells for treating the sensorineural hearing loss associated with transient ischemia of the cochlea2013

    • Author(s)
      Hakuba N
    • Organizer
      Politzer Society Meeting、(特別講演)
    • Place of Presentation
      トルコ
    • Year and Date
      20131114-17
  • [Presentation] The regeneration of tympanic membrane using basic fibroblast growth factor combined with an atelocollagen2013

    • Author(s)
      Hakuba N
    • Organizer
      European Academy of Otorhinolaryngology.(特別講演)
    • Place of Presentation
      フランス
    • Year and Date
      20130427-30
  • [Presentation] Regenerative therapy for closing tympanic membrane perforation using bFGF combined with atelocollagen . Global Otology Research Forum2013

    • Author(s)
      Hakuba N
    • Organizer
      Global Otology Research Forum、(特別講演、日本耳科学会代表講演)
    • Place of Presentation
      トルコ
    • Year and Date
      2013-11-13
  • [Presentation] The utility of cartilage with perichondrium & connective tissue for tympanoplasty2012

    • Author(s)
      Hakuba N
    • Organizer
      International of Cholesteatoma and middle ear surgery,(一般講演)
    • Place of Presentation
      長崎
    • Year and Date
      20120603-07
  • [Presentation] A new method for closing tympanic membrane perforations using basic fibroblast growth factor combined with an atelocollagen2012

    • Author(s)
      Hakuba N
    • Organizer
      International of Cholesteatoma and middle ear surgery、(特別講演)
    • Place of Presentation
      長崎
    • Year and Date
      20120603-07
  • [Presentation] The regenerative therapy for closing tympanic membrane perforations using bFGF combined with atelocollagen2012

    • Author(s)
      Hakuba N
    • Organizer
      The 14th Japan-Korea Joint Meeting of Otorhinolaryngology-Head and Neck Surgery
    • Place of Presentation
      長崎
    • Year and Date
      20120412-14
  • [Presentation] Hematopoietic stem cells prevent hair cell death after transcient cochlear ischemia2011

    • Author(s)
      Hakuba N, Yoshida T, Gyo K
    • Organizer
      Inner Ear Biology,(一般講演)
    • Place of Presentation
      ポルトガル
    • Year and Date
      20110918-21
  • [Presentation] 聴器の再生研究の進歩.日本学術会議臨床医学委員会感覚器分科会2011

    • Author(s)
      白馬伸洋
    • Organizer
      感覚器ロードマップ感覚器障害の克服と支援を目指す10年間,(公開シンポジウム)
    • Place of Presentation
      東京
    • Year and Date
      2011-08-09
  • [Book] 有毛細胞の再生、再生医療業書42013

    • Author(s)
      白馬伸洋、西田幸二、高橋政代編
    • Total Pages
      134-142
    • Publisher
      朝倉書店
  • [Book] 特集急性感音難聴の最新治療戦略急性感音難聴における新規治療の可能性人工酸素運搬体2012

    • Author(s)
      白馬伸洋
    • Total Pages
      28(5):807-810
    • Publisher
      JOHNS
  • [Book] bFGF徐放化ハイドロゲルを用いた鼓膜再生治療.田原泰彦監,ものづくり技術からみる再生医療―細胞研究・創薬・治療―2011

    • Author(s)
      白馬伸洋
    • Total Pages
      250-254
    • Publisher
      株式会社シーエムシー出版

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Published: 2015-07-16  

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