2013 Fiscal Year Final Research Report
Morphological regulation of the developmental inner ear hair cells by non-muscle myosin II
| Project/Area Number |
23592491
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
SAKAGUCHI Hirofumi 京都府立医科大学, 医学(系)研究科(研究院), 准教授 (00515223)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 内耳 / ミオシン / 上皮細胞 / 有毛細胞 / 蝸牛 / 聴覚 / サルコメア / 頂側結合 |
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| Research Abstract |
Non-muscle myosin II (NMII) is known to regulate cell shapes through the contraction of actin filaments, major components of the cytoskeleton. In muscle cells, NMII is known to form a complex which alined alternately with actin filaments and to provide force by contracting this "sarcomere" structure. On the other hand, the mechanism for providing NMII-based contraction force in the epithelial cells is still unclear. In this research, we demonstrated that NMII localized to the apical cell junction in the inner ear sensory epithelia, forming sarcomeric structures with the apical actin ring to provide string-like contraction force to the apical surface of the cells.
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[Journal Article] NMII forms a contractile transcellular sarcomeric network to regulate apical cell junctions and tissue geometry2013
Author(s)
Ebrahim S, Fujita T, Millis BA, Kozin E, Ma X, Kawamoto S, Baird MA, Davidson M, Yonemura S, Hisa Y, Conti MA, Adelstein RS, Sakaguchi H, Kachar B
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Journal Title
Curr Biol
Volume: 23
Pages: 731-6
Peer Reviewed
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