Analysis of miRNAs expression in the mouse inner ear

2013 Fiscal Year Final Research Report

• Project/Area Number: 23592501
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Otorhinolaryngology
• Research Institution: Kinki University
• Principal Investigator: DOI Katsumi 近畿大学, 医学部, 教授 (40243224)
• Project Period (FY): 2011 – 2013
• Keywords: miRNA / 内耳 / 蝸牛 / 前庭

Research Abstract

TRNA was separately extracted from each part of mouse inner ear, then miRNAs from organ of Corti, stria vascularis, lateral wall of cochlea, and vestibule system were analyzed. MiR-96, miR-182, and miR-183 were most abundant miRNAs in the mouse inner ear.

Research Products

• [Journal Article] 急性感音難聴.山口徹・北原光夫・福井次矢(編) (2013)
  • Author(s): 土井勝美
  • Journal Title: 今日の治療指針2013年度版.医学書院,東京 Pages: 1291-1292
• [Journal Article] 内耳内リンパ液の特殊電位環境の成立機構の理解 (2013)
  • Author(s): 日比野浩,任書晃,村上慎吾,土井勝美,鈴木敏弘,久育男,倉智嘉久
  • Journal Title: 日本耳鼻咽喉科学会会報 Volume: 116 Pages: 60-68
  • Peer Reviewed
• [Journal Article] 【プロに学ぶ手術所見の記載法】人工内耳手術 (2013)
  • Author(s): 土井勝美
  • Journal Title: JOHNS Volume: 29 Pages: 691-696
• [Journal Article] A case of cholesteatoma occurring after cochlear implantation. In Cholesteatoma and ear surgery an update Takahashi-H (ed) (2013)
  • Author(s): Ohta Y, Kawashima T, Hasegawa T, Uno A, Imai T, Morihana T, Higashi-Shingai K, Kamakura T, Suwa K, Hanamoto M, Michiba T, Doi K, Inohara H
  • Journal Title: Kugler Publications, Amsterdam, The Netherlands Pages: 377-380
• [Journal Article] Post-operative long-term hearing results in patients who underwent ossiculoplasties. In Cholesteatoma and ear surgery an update Takahashi-H (ed) (2013)
  • Author(s): Saito K, Isono M, Miyashita M, Sato M, Doi K
  • Journal Title: Kugler Publications, Amsterdam, The Netherlands Pages: 325-327
• [Journal Article] Congenital cholesteatoma of the middle ear : a report of 54 cases. In Cholesteatoma and ear surgery an update Takahashi-H (ed) (2013)
  • Author(s): Doi K, Sato M, Miyashita M, Saito K, Isono M, Terao K, Osaki Y, Morihana T, Ohta Y
  • Journal Title: Kugler Publications, Amsterdam, The Netherlands Pages: 143-145
  • Peer Reviewed
• [Journal Article] Surgical management of petrous apex cholesteatoma : our experience of 15 cases. In Cholesteatoma and ear surgery an update Takahashi-H (ed) (2013)
  • Author(s): Doi K, Sato M, Miyashita M, Saito K, Isono M, Terao K, SanadaA, Kato A
  • Journal Title: Kugler Publications, Amsterdam, The Netherlands Pages: 139-141
• [Journal Article] Stapes surgery and cochlear implant surgery for severe otosclerosis. In Cholesteatoma and ear surgery an update Takahashi-H (ed) (2013)
  • Author(s): Doi K, Sato M, Miyashita M, Saito K, Isono M, Terao K, Koizuka I, Ohta Y
  • Journal Title: Kugler Publications, Amsterdam, The Netherlands Pages: 111-113
• [Journal Article] Evaluation of middle ear pneumatization after planned tw0-staged tympanoplasty for cholesteatoma : its correlations with hearing results and recurrence rates. In Cholesteatoma and ear surgery an update Takahashi-H (ed) (2013)
  • Author(s): Doi K, Fukusumi T, Osaki Y, Yasui T, Hasegawa T, Morihana T, Ohta Y
  • Journal Title: Kugler Publications, Amsterdam, Publica tions, Amsterdam, The Netherlands Pages: 59-61
• [Journal Article] Cholestetoma growth and proliferation:expression of HGF (Hepatocyte Growth Factor) and its high-affinity receptor C-MET. In Cholesteatoma and ear surgery an update Takahashi-H (ed) (2013)
  • Author(s): Doi K
  • Journal Title: Kugler Publications, Amsterdam, The Netherlands Pages: 29-31
• [Journal Article] 突発性難聴.,山口徹・北原光夫・福井次矢編 (2013)
  • Author(s): 土井勝美
  • Journal Title: 今日の治療指針2012年度版,医学書院,東京 Pages: 1255
• [Journal Article] メニエール病の外科治療. 内藤泰編 (2012)
  • Author(s): 土井勝美
  • Journal Title: ENT臨床フロンテイア「めまいを見分ける治療する」中山書書店,東京 Pages: 314-322
• [Journal Article] 急性感音難聴の治療戦略-メエール病 (2012)
  • Author(s): 土井勝美
  • Journal Title: JOHNS Volume: 28 Pages: 767-771
• [Journal Article] 突発性難聴とめまい (2012)
  • Author(s): 土井勝美
  • Journal Title: Clinical Neuroscience Volume: 30 Pages: 77-78
• [Journal Article] 反復するめまいへの対応:メニエール病 (2011)
  • Author(s): 土井勝美
  • Journal Title: ENTONI Volume: 136 Pages: 1-7
• [Journal Article] 私の処方箋:良性発作性頭位めまい症 (2011)
  • Author(s): 土井勝美
  • Journal Title: JOHNS Volume: 27 Pages: 1328-1330
• [Journal Article] Cochlear changes in presbycusis with tinnitus (2011)
  • Author(s): K Terao, S Cureoglu, S Schachern, N Morita, S Nomiya, AF Deroee, K Doi, K Mori, K Murata
  • Journal Title: Am J Otolaryngol HNS Volume: 32 Pages: 215-220
  • Peer Reviewed
• [Journal Article] Marrow-Middle ear connections : a potential cause of otogenic meningitis (2011)
  • Author(s): K Terao, S Cureoglu, S Schachern, MM Paparella, N Morita, T Sato, K Mori, K Murata, K Doi
  • Journal Title: Otol Neurotol Volume: 32 Pages: 77-80
  • Peer Reviewed
• [Journal Article] めまいのup date?めまいの急性期治療と炭酸水素ナトリウム (2010)
  • Author(s): 土井勝美
  • Journal Title: クリニシアン Volume: 57 Pages: 283-287
• [Journal Article] 人工内耳医療の過去・現在・未来 (2010)
  • Author(s): 土井勝美
  • Journal Title: 耳鼻臨床 Volume: 103 Pages: 973-982
  • Peer Reviewed
• [Journal Article] 小児人工内耳の言語獲得におけるEBM (2010)
  • Author(s): 土井勝美
  • Journal Title: EBM耳鼻咽喉科・頭頸部腫瘍の治療2010-2011中外医学社.東京 Pages: 179-182
• [Journal Article] 小児人工内耳医療の将来展望 (2010)
  • Author(s): 土井勝美
  • Journal Title: 耳展 Volume: 53 Pages: 400-407
  • Peer Reviewed
• [Journal Article] 外リンパ瘻.,山口徹・北原光夫・福井次矢編 (2010)
  • Author(s): 土井勝美
  • Journal Title: 今日の治療指針2010年度版,医学書院,東京 Pages: 1203-1204
• [Journal Article] Incidence of revision cochlear implantation in both children and adults (2010)
  • Author(s): K. Doi, Y. Osaki, T. Kawashima, K. Ohata, T. Yoshinami, K. Suwa, H. Inohara, S. Hio, T. Sato, H. Nishimura
  • Journal Title: Proceedings of the 7th Asia Pacific Symposium on Cochlear Implants and Related Sciences, Medimond, Bologna, Italy Pages: 111-115
• [Journal Article] Benefits of cochlear implantation in elderly patients (2010)
  • Author(s): S. Hio, K. Doi, Y. Osaki, K. Ohata, K. Suwa, M. Hanamoto, H. Inohara, T. Hasegawa
  • Journal Title: Proceedings of the 7th Asia Pacific Symposium on Cochlear Implants and Related Sciences, Medimond, Bologna, Italy Pages: 117-120
• [Journal Article] Activation of the auditory cortex in a child with a cochlear implant : an optical topography study (2010)
  • Author(s): Y. Osaki, K. Doi, C. Masumura, K. Suwa, M. Hanamoto, H. Inohara
  • Journal Title: Proceedings of the 7th Asia Pacific Symposium on Cochlear Implants and Related Sciences, Medimond, Bologna, Italy Pages: 175-178
• [Journal Article] Clinical characteristics of delayed endolymphatic hydrops in Japan : A nationwide survey by the Peripheral Vestibular Disorder Research Committee of Japan (2010)
  • Author(s): H. Shojaku, Y. Watanabe, N.Takeda, T. Ikezono, M. Takahashi, A.Kakigi, J. Ito, K. Doi, M. Suzuki, M. Takumida, K. Takahashi, H. Yamashita, I. Koizuka, S. Usami, M. Aoki, H.Naganuma
  • Journal Title: Acta Otolaryngol Volume: 130 Pages: 1135-40
  • Peer Reviewed
• [Journal Article] Marrow-middle ear connections : a potential cause of otogenic meningitis (2010)
  • Author(s): K. Terao, S. Cureoglu, PA. Schachern, MM. Paparella, N. Morita, T. Sato, K. Mori, K. Murata, K. Doi
  • Journal Title: Otol Neurotol Volume: 32 Pages: 77-80
• [Journal Article] Tinnitus as a prognostic factor of sudden deafness (2010)
  • Author(s): N. Hikita-Watanabe, T. Kitahara, A. Horii, T. Kawashima, K. Doi, SI. Okumura
  • Journal Title: Acta Otolaryngol Volume: 130 Pages: 79-83
• [Journal Article] Behavioral assessment and identification of a molecular marker in a salicylate-induced tinnitus in rats (2010)
  • Author(s): K. Kizawa, T. Kitahara, A. Horii, C. Maekawa, T. Kuramasu, T. Kawashima, S. Nishiike, K. Doi, H. Inohara
  • Journal Title: Neuroscience Volume: 165 Pages: 1323-32
  • Peer Reviewed
• [Journal Article] Expression and translocation of aquaporin-2 in the endolymphatic sac in patients with Meniere's disease (2010)
  • Author(s): C Maekawa, T. Kitahara, K. Kizawa, S. Okazaki, T. Kamakura, A. Horii, T. Imai, K. Doi, H. Inohara, H. Kiyama
  • Journal Title: J Neuroendocrinol Volume: 22 Pages: 1157-1164
  • Peer Reviewed
• [Presentation] 正円窓経由の人工内耳手術-CT画像による正円窓窩評価 (2013)
  • Author(s): 土井勝美,佐藤満雄,小林孝光,宮下美恵,斎藤和也,磯野道夫
  • Organizer: 第23回日本耳科学会
  • Place of Presentation: 宮崎市
  • Year and Date: 20131124-26
• [Presentation] ilateral VSB implantation : the first experience (2013)
  • Author(s): DoiK
  • Organizer: New Trends in Hearing Implant Science
  • Place of Presentation: Hakuba, Japan
  • Year and Date: 20131026-27
• [Presentation] 小児人工内耳手術-正円窓経由の電極挿入 (2013)
  • Author(s): 土井勝美,佐藤満雄,小林孝光,宮下美恵,斎藤和也
  • Organizer: 第8回日本小児耳鼻咽喉科学会
  • Place of Presentation: 前橋市
  • Year and Date: 20130620-21
• [Presentation] Expression of HERG and ERG channels in the rat cochlea (2012)
  • Author(s): Sato M, Miyashita M, Saito K, Terao K, Doi K
  • Organizer: IEB
  • Place of Presentation: Tubingen, Germany
  • Year and Date: 20120929-1002
• [Presentation] Expressions of HGF and its high-affinity receptor C-MET in the early developing rat cochlea.IEB (2012)
  • Author(s): Doi K, Sato M, Miyashita M, Saito K, Terao K
  • Organizer: IEB
  • Place of Presentation: Tubingen, Germany
  • Year and Date: 20120929-1002
• [Presentation] Congenital cholesteatoma of the middle ear : a report of 54 cases (2012)
  • Author(s): Doi K, Sato M, Miyashita M, Saito K, Isono M, Terao K, Osaki Y, Morihana T, Ohta Y
  • Organizer: Cholesteatoma 2012
  • Place of Presentation: Nagasaki, Japan
  • Year and Date: 20120604-06
• [Presentation] Surgical management of petrous apex cholesteatoma : our experience of 15 cases (2012)
  • Author(s): Doi K, Sato M, Miyashita M, Saito K, Isono M, Terao K, Sanada A, Kato A
  • Organizer: Cholesteatoma 2012
  • Place of Presentation: Nagasaki, Japan
  • Year and Date: 20120604-06
• [Presentation] Cholesteatoma growth and proliferation : Expression of HGF (Hepatocyte Growth Factor) and its high-affinity receptor C-MET (2012)
  • Author(s): Doi K
  • Organizer: Cholesteatoma 2012
  • Place of Presentation: Nagasaki, Japan
  • Year and Date: 20120604-06
• [Presentation] Stapes surgery and cochlear implant surgery for severe ortosclerosis (2012)
  • Author(s): Doi K, Sato M, Miyashita M, Saito K, Isono M, Terao K, Koizuka I, Ohta Y
  • Organizer: Cholesteatoma 2012
  • Place of Presentation: Nagasaki, Japan
  • Year and Date: 20120604-06
• [Presentation] Evaluation of middle ear pneumatization after planned two-staged tympanoplasty for cholesteatoma : its correlations with hearing results and recurrence rates (2012)
  • Author(s): Doi K, Fukusumi T, Osaki Y, Yasui, Hasegawa T, Morihana T, Ohta Y
  • Organizer: Cholesteatoma 2012
  • Place of Presentation: Nagasaki, Japan
  • Year and Date: 20120604-06
• [Presentation] 聴力保存を目指した人工内耳手術-正円窓膜経由の電極挿入 (2012)
  • Author(s): 土井勝美,佐藤満雄,小林孝光,宮下美恵,斎藤和也,磯野道夫,寺尾恭一
  • Organizer: 第22回日本耳科学会
  • Place of Presentation: 名古屋
  • Year and Date: 2012-10-06
• [Presentation] 正円窓経由の電極挿入による人工内耳手土術 (2012)
  • Author(s): 土井勝美,佐藤満雄,宮下美恵,斎藤和也,磯野道夫,寺尾恭一
  • Organizer: 第113回日本耳鼻咽喉科学会総会・学術講演会
  • Place of Presentation: 新潟
  • Year and Date: 2012-05-11
• [Presentation] 人工内耳症例の普通小学校への進学率 (2011)
  • Author(s): 土井勝美,宮下美恵,佐藤満雄,斎藤和也,寺尾恭一,磯野道夫,長谷川太郎,太田有美,宇野敦彦,猪原秀典,諏訪圭子
  • Organizer: 第21回日本聴覚医学会
  • Place of Presentation: 沖縄
  • Year and Date: 20111124-26
• [Presentation] Binaural advantage in CI patients (2011)
  • Author(s): K. Doi
  • Organizer: APSCI2012
  • Place of Presentation: Korea
  • Year and Date: 20111026-28
• [Presentation] Cochlear implantation in patients with middle ear disease (2011)
  • Author(s): Ohta, K. Doi, T. Hasegawa, T. Kawashima, K. Suwa, M. Hanamoto, H. Nishimura, Y. Osaki, H. Inohara
  • Organizer: APSCI2012
  • Place of Presentation: Korea
  • Year and Date: 20111026-28
• [Presentation] Successful cochlear implantation in the case of eosiophilic otitis media with bilateral, progressive and profound sensorineural hearing loss (2011)
  • Author(s): M. Miyashia, M. Sato, K. Saito, K. Terao, K. Doi
  • Organizer: APSCI2012
  • Place of Presentation: Korea
  • Year and Date: 20111026-28
• [Presentation] Scala vestibuli cochlear implantation in the case of cochlear incomplete partition with CSF gusher and persistent bleeding via cochleostomy opening of scala tympani (2011)
  • Author(s): M. Sato, M. Miyashia, K. Saito, K. Terao, K. Doi
  • Organizer: APSCI2012
  • Place of Presentation: Korea
  • Year and Date: 20111026-28
• [Presentation] Residual hearing after ordinary cochlear implant surgery with scala tympani cochleostomy and full-electrodes insertion (2011)
  • Author(s): K. Doi, M. Miyashia, M. Sato, K.Saito, K. Terao, K. Suwa, H. Inohara, Y. Ohta, T. Hasegawa, T. Morihana
  • Organizer: APSCI2012
  • Place of Presentation: Korea
  • Year and Date: 20111026-28
• [Presentation] 人工聴覚器の将来:人工中耳-BAHAとVSB (2011)
  • Author(s): 土井勝美
  • Organizer: 第112回日本耳鼻咽喉科学会
  • Place of Presentation: 京都
  • Year and Date: 20110519-21
• [Presentation] 人工内耳手術前後の骨導閾値の変化 (2010)
  • Author(s): 土井勝美,村本大輔,長谷川太郎,太田有美,諏訪圭子,大崎康宏,藤本揚子
  • Organizer: 第55回日本聴覚医学会
  • Place of Presentation: 奈良
  • Year and Date: 20101110-12
• [Presentation] 人工内耳手術前後の骨導閾値変化 (2010)
  • Author(s): 土井勝美,佐藤満雄,藤原良平,斎藤和也,村本大輔,寺尾恭一,磯野道夫,長谷川太郎,太田有美,諏訪圭子,猪原秀典
  • Organizer: 第20回日本耳科学会
  • Place of Presentation: 愛
  • Year and Date: 20101006-09