2013 Fiscal Year Final Research Report
Age-related olfactory dysfunction: cellular and molecular analyses
| Project/Area Number |
23592506
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
KONDO Kenji 東京大学, 医学部附属病院, 講師 (40334370)
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| Co-Investigator(Renkei-kenkyūsha) |
YAMASOBA Tatsuya 東京大学, 医学部附属病院, 教授 (60251302)
SUZUKAWA Keigo 東京大学, 医学部附属病院, 助教 (50447398)
USHIO Munetak 東京大学, 医学部附属病院, 助教 (70361483)
KANAYA Kaori 東京大学, 医学部附属病院, 助教 (90456129)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 鼻科学 / 嗅覚障害 / 加齢変化 / カロリー制限 / エストロゲン / 感冒罹患後嗅覚障害 / FAT-1マウス |
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| Research Abstract |
1. Caloric restriction exacerbated the age-related neuroepithelial degeneration in the mouse olfactory mucosa and also worsened the regeneration of the olfactory neuroepithelium after injury. The downregulation of proliferative activity in neuroepithelium by caloric restriction appeared to play an important role in the pathogenesis. 2. The immune model of postviral olfactory disorder (PVOD) was developed in mice using Poly(I:C), a synthetic analog of viral double-stranded RNA. The analyses suggested that the secondary damage caused by the neutrophil-mediated innate immune response plays an important role in the pathogenesis of PVOD. 3. The analyses of estrogen receptor beta (ERbeta) -deficient mice suggested that estrogen plays a role in the homeostasis of the olfactory mucosa through ERbeta. 4. FAT-1 mice demonstrated better neuroepithelical regeneration after injury, suggesting that the tissue fatty acid is associated with the regeneration of the olfactory neuroepithelium.
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