2013 Fiscal Year Final Research Report
Mucosal immunity in the upper respiratory tract
| Project/Area Number |
23592512
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Oita University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
HIRANO Takashi 大分大学, 医学部, 講師 (20305056)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 粘膜免疫 / 樹状細胞 / NKT細胞 / 上気道 |
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| Research Abstract |
The efficacy of alpha-galactosylceramide (aGalCer) as a mucosal adjuvant was examined. Mice were immunized intranasally with nontypeable Haemophilus influenzae (NTHi) P6 protein and a-GalCer. P6-specific antibody responses in the form of P6-specific IgA in nasal washes and serum IgG titers were significantly elevated. Splenic CD4+ T cells expressed P6-specific Th1 and Th2 cytokine mRNA. In addition, NTHi was quantified in nasal washes following NTHi challenges, and the clearance of NTHi from the nasopharynx was also enhanced. These results indicate that aGalCer might be an effective mucosal adjuvant.
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