2013 Fiscal Year Final Research Report
Effect of Transcutaneous immunotherapy in Allergic Rhinitis
| Project/Area Number |
23592516
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Osaka Medical College |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2013
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| Keywords | スギ花粉症 / 経皮的免疫療法 / TSLP |
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| Research Abstract |
Subcutaneous allergen-specific immunotherapy is an effective treatment of IgE-mediated allergies, but it requires repeated allergen injections with a risk of systemic allergic reactions. Transcutaneous immunotherapy may improve patient compliance and safety. Our first aim is to investigate the effect of transcutaneous immunotherapy in Allergic Rhinitis.
And also, we investigated the expression of TSLP in cytokine-treated nasal polyp fibroblasts. Nasal polyp fibroblasts have the capacity to produce TSLP in response to stimulation by tumor necrosis factor (TNF) alpha. Combined stimulation with TNF-alpha a Th2 cytokine (IL-4) was synergistic for TSLP production by the nasal polyp fibroblasts. TSLP production was strongly inhibited by interferon gamma but not by IL-10.
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Research Products
(2 results)
