2013 Fiscal Year Final Research Report
Network of signaling pathway of head and neck cancer
| Project/Area Number |
23592517
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
HOMMA Akihiro 北海道大学, 大学院医学研究科, 准教授 (30312359)
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| Project Period (FY) |
2011 – 2013
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| Keywords | シグナル伝達 / 上皮成長因子受容体（EGFR) / リガンド |
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| Research Abstract |
Signaling pathways associated with the growth of cancer cell have been gradually revealed and the regulation of the pathway has been applied to treatment of various cancers. We identified the cluster of molecular which associated with the cross-talk of signaling pathway and epithelial-mesenchymal transition of head and neck cancer cells using the genome-proteome analysis. Furthermore, we find that the sensitivity to cetuximab, monoclonal antibody of epidermal growth factor receptor (EGFR), was correlated with the expression of EGFR itself and the level of ligands to EGFR. The regulation of the ligands might contributed to enhance the effect of cetuximab and expected to overcome the resistance to cetuximab
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[Journal Article] Regional control after concomitant chemoradiotherapy without planned neck dissection in node-positive head and neck squamous cell carcinomas2013
Author(s)
Sakashita T, Homma A, Oridate N, Suzuki S, Hatakeyama H, Kano S, Mizumachi T, Onimaru R, Tsuchiya K, Yasuda K, Shirato H, Fukuda S
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Journal Title
Auris Nasus Larynx
Volume: 40
Pages: 211-215
Peer Reviewed
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[Journal Article] Combined modality therapy for laryngeal cancer with superselective intra-arterial cisplatin infusion and concomitant radiotherapy2012
Author(s)
Taki S, Homma A, Suzuki F, Oridate N, Hatakeyama H, Mizumachi T, Kano S, Furusawa J, Sakashita T, Inamura N, Yoshida D, Onimaru R, Shirato H, Fukuda S
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Journal Title
Int J Clin Oncol
Volume: 17
Pages: 441-6
Peer Reviewed
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